Effects of Ultrasonic Debridement With PVP-iodine Irrigation on Post-treatment Bacteraemia Compared to Ultrasonic Debridement With Water
Overview
- Phase
- Phase 4
- Intervention
- Supra- and subgingival rinsing with 10% PVP-iodine
- Conditions
- Bacteraemia Post Debridement
- Sponsor
- University of Zurich
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- quantity of bacteraemia in central blood stream
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The study investigates the effect of supra- and subgingival rinsing of 10% PVP prior to ultrasonic debridement in patients with periodontitis (as compared to rinsing with water) in terms of post treatment bacteraemia.
Study design: Randomized split-mouth (cross-over) study on 20 generally healthy subjects.
Detailed Description
Process: Test treatment: * 1 min mouthwash with 10% PVP-iodine * 1 min subgingival rinsing with 10% PVP-iodine * 1 min ultrasonic debridement with 10% PVP-iodine as cooling liquid * blood sampling from the V.mediana cupidi Control: * 1 min mouthwash with water * 1 min subgingival rinsing with water * 1 min ultrasonic debridement with water as cooling liquid * blood sampling from the V.mediana cupidi lysis, culturing and analysis of bacteria in the samples
Investigators
Eligibility Criteria
Inclusion Criteria
- •generally healthy, adult (≥ 18 years) patients with at least two periodontal pockets of ≥ 5 mm
Exclusion Criteria
- •Pregnancy
- •Lactation
- •Allergy on PVP-iodine
- •anticoagulation (exception 100mg/d acetylsalicylic acid)
- •high risc for endocarditis
- •therapeutical radiation
- •participation in other clinical studies
- •cognitive impairment (patient unable to understand aim and conduction of the study
Arms & Interventions
test treatment
Test treatment: * 1 min mouthwash with 10% PVP-iodine * 1 min subgingival rinsing with 10% PVP-iodine * 1 min ultrasonic debridement with 10% PVP-iodine as cooling liquid * blood sampling from the V.mediana cupidi
Intervention: Supra- and subgingival rinsing with 10% PVP-iodine
Control group
Control: * 1 min mouthwash with water * 1 min subgingival rinsing with water * 1 min ultrasonic debridement with water as cooling liquid * blood sampling from the V.mediana cupidi
Intervention: Water
Outcomes
Primary Outcomes
quantity of bacteraemia in central blood stream
Time Frame: three minutes after starting debridement
In how many samples a bacterial contamination is found?
quality of bacteraemia in central blood stream
Time Frame: three minutes after starting debridement
How many CFU are found in each blood sample?