NCT00324207已完成不适用
Prediction of Type 1 Diabetes: Molecular Quantification of Insulin mRNA in the While Cell Fraction of Whole Blood
Children's Mercy Hospital Kansas City1 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2006年2月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 400
- 试验地点
- 1
研究概览
简要总结
The objectives of this study are to:
- quantitate the level of insulin mRNA in the while cell fraction of whole blood in selected groups of subjects,
- determine the gene expression of markers of white cell activation in the white cell fraction of whole blood in selected subjects,
- determine the identity of the white cell responsible for expression of insulin mRNA and
- determine protein expression of mRNA of insulin/proinsulin and selected genes of white cell activation.
详细描述
Indicators of active immune or chemically mediated beta cell destruction would be helpful for predicting the development and severity of autoimmune diabetes and monitoring the success of islet transplants. Currently there are no reliable indicators readily available.
Insulin mRNA in the white cell fraction of blood has been detected or elevated under several circumstances including:
- normal animals
- after islet cell transplantation
- hyperglycemic induced expression and
- during induction of diabetes with streptozotocin
The investigators propose that quantitative measurement of insulin mRNA may be an accurate, innovative and minimally invasive indicator of beta cell destruction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female subjects ages 1 to 17 years of age
- •Subjects with evidence of beta cell dysfunction or evidence of beta cell autoimmunity
- •Subjects with new onset type 1 diabetes
- •Non-diabetic and autoantibody negative siblings of subjects with new onset type 1 diabetes
- •Unrelated nondiabetic controls with no family history of type 1 diabetes
- •Of sufficient size to donate 10ml of blood
排除标准
- •None if subjects meet above inclusion criteria
研究者
研究点 (1)
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