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Clinical Trials/NCT03551717
NCT03551717
Terminated
Not Applicable

Retinal Microvascularization and Cardiovascular Diseases

Centre Hospitalier Universitaire Dijon1 site in 1 country155 target enrollmentMarch 14, 2018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
High Cardiovascular Risk Patients
Sponsor
Centre Hospitalier Universitaire Dijon
Enrollment
155
Locations
1
Primary Endpoint
Surface of the avascular zone in the central retina
Status
Terminated
Last Updated
5 years ago

Overview

Brief Summary

The main objective of this study is to investigate whether there are links between the blood vessels of the retina as a whole and heart and/or vascular diseases (cardiovascular diseases).

The arteries and veins of the retina are, like the large vessels of the human body (aorta, coronary, cerebral arteries), exposed to the complications of hypertension, diabetes, obesity, dyslipidemia (abnormal blood lipid profile) or tobacco. Several studies have shown that changes in retinal vessels (microvascularization) generally occur several years before damage to large peripheral vessels (macrovascularization). The study of the vessels of the retina is now possible thanks to simple and non-invasive examinations of photographs (not creating any lesion). They allow a painless evaluation of the vessels in the retina.

Ultimately, if this study is conclusive, the patient's cardiovascular risk could be evaluated simply by analysis of the vessels of the retina.

The study is being conducted in the ophthalmology and cardiology departments of Dijon University Hospital. In total, the investigators wish to include approximately 510 patients who present cardiovascular risk factors (255 low risk patients recruited in the ophthalmology department and 255 high risk patients hospitalized in the cardiology department).

All patients participating in the study will be asked to visit the ophthalmology department for a complete examination of the retina.

Registry
clinicaltrials.gov
Start Date
March 14, 2018
End Date
April 19, 2019
Last Updated
5 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Person who gave oral consent
  • High cardiovascular risk group: Adult patients hospitalized in the Cardiology Department of the University Hospital of Dijon Burgundy for acute coronary syndrome, patients between D1 and D5 of acute coronary syndrome, who can be moved for an ophthalmology consultation where the retinal imaging is done (heart monitoring in the presence of an experienced cardiologist if necessary)
  • Low cardiovascular risk group: Adult patients over 40 years of age recruited in the Ophthalmology Department of the University Hospital of Dijon Burgundy following a standard consultation for cataract surgery, ocular surface pathologies and optical correction.

Exclusion Criteria

  • Person not affiliated to national health insurance
  • Patient refusal
  • Minor patient
  • Protected patient
  • Ophthalmological history (macular vascular or degenerative disorders)

Outcomes

Primary Outcomes

Surface of the avascular zone in the central retina

Time Frame: Baseline

Study Sites (1)

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