The Impact of Soft Contact Lenses on the Corneal Neuromediators and Optical Quality in High Myopia Prior to SMILE
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Corneal stromal lenticule Neuromediators
研究概览
简要总结
To investigate the influence of Neuromediators expression in corneal stromal lenticules and corneal injury repair after small incision extraction
详细描述
This study included 160 eyes from high myopia patients who underwent Small Incision Lenticule Extraction. Patients were devided into three groups based on duration of wearing SCLs: > 10 years group, ≤ 10 years group, and NW group (not SCLs). Corneal higher-order aberrations and densitometry were evaluated using a Pentacam system. Neuromediator levels in corneal stromal lenticules were analyzed using ELISA and immunofluorescence
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age ≥ 18 years with stable refraction for at least two years;
- •spherical equivalent (SE) < -6.00 D;
- •corrected distance visual acuity of 20/20 or better;
- •no history of using rigid gas permeable lenses or orthokeratology (OK) lenses prior to examination
排除标准
- •a history of moderate to severe dry eye as well as any ocular or systemic disease that would contraindicate laser refractive surgery.
结局指标
主要结局
Corneal stromal lenticule Neuromediators
时间窗: baseline
Corneal neuromediators, including NGF(pg/mL), CGRP(pg/mL), SP(pg/mL), IGFBP-1(ng/mL), and MANF(pg/mL), which play pivotal roles in maintaining normal physiological functions of the cornea.
次要结局
- Corneal Aberration(baseline)
- Corneal Densitometry(baseline)
研究者
yuhao shao
MD
Tongji University