COMPARISON BETWEEN TWO METHODS OF OXYGEN CONCENTRATION MEASUREMENT DURING PREOXYGENATION BEFORE CRASH INDUCTION

Not yet recruiting

Conditions: Factors influencing health status and contact with health services,

Registration Number: CTRI/2023/06/054224

Lead Sponsor: Vardhman Mahavir Medical College and Safdarjung Hospital

Brief Summary: . Difficult airwaysociety suggests that when critically ill patients are intubated,preoxygenation should be performed until an End tidal oxygen level of greaterthan or equal to 85% is attained.

Effectiveness ofpreoxygenation can be assessed by values of oxygen saturation on pulse oximeter(SpO2 ) and End tidal oxygen [ETO2].Although SpO2 is gold standard for assessing adequacy ofpreoxygenation as it is inexpensive and easily accessible. However it is anindirect measure of preoxygenation.

In earlier times ETO2was not included for standard monitoring as it was expensive and not easilyavailable. Therefore there was paucity of literature for assessing efficacy ofpreoxygenation using ETO2. With advancement of technology,availability of modern equipment, end tidal oxygen monitoring is feasible andshould be considered as a monitoring standard for adequacy of preoxygenation .There is paucity of literature supporting the use of ETO2 as a guide forpreoxygenation particularly in Indian hospital set up

Patient will be taken as per inclusion criteria. Preanesthetic evaluation of the patient. Written informed consent taken from patient. Patient taken to operation theatre, monitoring established, baseline vitals noted, monitoring of SpO2 and ETO2 concentration at the start of preoxygenation

Preoxygenation for 3 minutes with 100% oxygen

Monitoring of SpO2 and ETO2 concentration at the end of preoxygenation

Induction with Fentanyl, thiopentone or etomidate followed by suxamethonium

Apnoeic oxygenation 100% oxygen for 45 seconds

Monitoring of SpO2 and ETO2 concentration at the end of intubation / beginning of capnographic waveform

n=70

Confirmation of achieving effective ventilation

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

ASA I-III physical state undergoing rapid sequence intubation.

Exclusion Criteria

1.Patients already on oxygen therapy 2.Anticipated difficult intubation.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to compare end tidal oxygen concentration & hemoglobin saturation of oxygen at the end of preoxygenation.	at 0 mins & 3 mins

Secondary Outcome Measures

Name	Time	Method
to compare end tidal oxygen concentration & hemoglobin saturation of oxygen at the start of preoxygenation and at the end of intubation	at 0 mins & 3.45 mins

Trial Locations

Locations (1): Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029
🇮🇳
Delhi, DELHI, India
Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029
🇮🇳Delhi, DELHI, India
Pooja Nagar
Principal investigator
9868242633
Nagar0700@gmail.com