Iron Absorption and Exercise

Not Applicable

Completed

• Conditions: Iron-deficiency; Iron Deficiency Anemia
• Interventions: Other: Meal

• Registration Number: NCT04079322
• Lead Sponsor: Florida State University

Brief Summary

Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-08-12
• Study Start: 2019-08-22
• Study First Submitted QC: 2019-09-04
• Study First Posted: 2019-09-06
• Primary Completion: 2019-12-04
• Study Completion: 2019-12-04
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-25
• Last Update Posted: 2020-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• Members of the Florida State University Cross Country team
• Refrain from using any pain-relievers (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs such as aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product on the 2 study days
• Refrain from using vitamin or mineral supplements on the study days

Exclusion Criteria

• Musculoskeletal injury that compromise the ability to exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Rest	Meal	The rest arm will be coordinated with a planned non-workout day, as prescribed by the coach, where volunteers are either scheduled to not run or go for an easy recovery run (\<6 miles at a self-described "easy" pace) later in the afternoon.
Exercise	Meal	During the exercise arm, volunteers will complete a planned workout, as prescribed by the coach. The workout will be designed to be strenuous and induce an inflammatory response.

Primary Outcome Measures

Name	Time	Method
Change in fractional iron absorption	Red blood cells collected on day 0 and day 14	Stable iron isotopes

Secondary Outcome Measures

Name	Time	Method
Change in concentration of hepcidin in ng/mL	Day 0 and day 14	Blood measure
Change in concentration of ferritin in ng/mL	Day 0 and day 14	Blood measure
Change in concentration of soluble transferrin receptor in nmol/L	Day 0 and day 14	Blood measure
Change in concentration of IL-6 in pg/mL	Day 0 and day 14	Blood measure
Change in concentration of hemoglobin in g/L	Day 0 and day 14	Blood measure
Change in concentration of hematocrit as %	Day 0 and day 14	Blood measure

Trial Locations

Locations (1)

Florida State University; 🇺🇸 Tallahassee, Florida, United States