Chronobiological Determinants of Gut Microbiome: The Effects of Meal Timing and Eating Frequency
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Gut microbial profiles of participants
研究概览
简要总结
The aim of this study is to examine how the number of daily eating occasions and the timing of energy intake influence gut microbiome composition in both morbidly obese and non-obese individuals. The analysis is based on baseline data from a case-control study involving 11 non-obese and 23 morbidly obese adults. Participants were excluded if they were younger than 19 or older than 65 years, had an acute or chronic inflammatory condition, had been diagnosed with an infectious disease, cancer, or alcohol dependence, or had used antibiotics within the three months prior to screening.
详细描述
This study aimed to investigate how the number of daily eating occasions and the timing of energy intake influence gut microbiome composition in morbidly obese and non-obese adults. This case-control study examined the gut microbiota of 23 morbidly obese individuals (BMI > 40 kg/m²) and 11 non-obese individuals (BMI < 30 kg/m²).
Dietary intake was assessed using 24-hour dietary recall records. From these data, the number of meals, total daily energy intake, and the proportion of energy consumed within specific time intervals (06:00-13:00, 13:00-20:00, and 20:00-06:00) were calculated. Energy intake occurring after 20:00 was defined as nighttime eating.
Participant eligibility required individuals to be between 19 and 65 years of age, free from acute or chronic inflammatory diseases, and without diagnoses of infectious diseases, cancer, or alcohol addiction. Additionally, participants were excluded if they had taken antibiotics within the three months preceding the screening.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 26 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged 19 to 65 years Morbid obesity (case group) Non-obese status, including lean or pre-obese (control group) Willingness to participate in the study Ability to provide informed consent
排除标准
- •Age < 26 years or > 60 years Presence of acute or chronic inflammatory diseases Diagnosis of infectious diseases History of cancer Alcohol addiction Use of antibiotics within 3 months prior to screening
结局指标
主要结局
Gut microbial profiles of participants
时间窗: Baseline
Gut microbial profiles of participants at phylum and sub-phylum levels
Meal frequency of participants
时间窗: Baseline
Number of meals consumed per day
Total daily energy intake
时间窗: Baseline
Total daily energy intake assessed from dietary data (kcal/day)
Distribution of energy intake by time of day
时间窗: Baseline
Percentage of total daily energy intake consumed during predefined time periods of the day (e.g., morning, afternoon, evening, night)
次要结局
未报告次要终点
研究者
Aslihan Ozdemir
Assistant Professor
Hacettepe University