Benefit of CFAE Ablation

Not Applicable

Completed

• Conditions: Persistent Atrial Fibrillation

• Registration Number: NCT01711047
• Lead Sponsor: Oxford University Hospitals NHS Trust

Brief Summary

The optimal strategy for catheter ablation of persistent atrial fibrillation is not clearly defined. This study investigates if Complex Fractionated Atrial Electrogram (CFAE) ablation in addition to pulmonary vein isolation and linear ablations improves single procedural success rate over a 12 month follow up period.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2012-10-12
• Study First Submitted QC: 2012-10-17
• Study First Posted: 2012-10-22
• Primary Completion: 2013-08
• Study Completion: 2013-08
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-11
• Last Update Posted: 2017-10-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• persistent atrial fibrillation

Exclusion Criteria

• previous catheter or surgical ablation for atrial fibrillation
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Single procedural success rate (free from AF off anti-arrhythmic drugs)	12 MONTHS

Secondary Outcome Measures

Name	Time	Method
Percentage of AF termination	Time 0	This information will be recorded immediately after the procedure.
recurrence of atrial fibrillation or organised atrial tachycardia	12 months after the last procedure
Ablation time	Time 0	This information will be recorded immediately after the procedure.
Procedure time	Time 0	This information will be recorded immediately after the procedure
Multiple procedure success rate	12 months after last ablation
Complication rate	30 days of procedure

Trial Locations

Locations (2)

Royal Bournemouth Hospital; 🇬🇧 Bournemouth, United Kingdom

John Radcliffe Hospital; 🇬🇧 Oxford, United Kingdom