Benefit of CFAE Ablation
Not Applicable
Completed
- Conditions
- Persistent Atrial Fibrillation
- Interventions
- Procedure: Radiofrequency catheter ablation
- Registration Number
- NCT01711047
- Lead Sponsor
- Oxford University Hospitals NHS Trust
- Brief Summary
The optimal strategy for catheter ablation of persistent atrial fibrillation is not clearly defined. This study investigates if Complex Fractionated Atrial Electrogram (CFAE) ablation in addition to pulmonary vein isolation and linear ablations improves single procedural success rate over a 12 month follow up period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
- persistent atrial fibrillation
Exclusion Criteria
- previous catheter or surgical ablation for atrial fibrillation
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description PVI + linear ablation + CFAE Radiofrequency catheter ablation Arm B: patients have PVI + roof and mitral isthmus lines and CFAE ablation PVI + Linear ablation Radiofrequency catheter ablation Arm A: patients have PVI and roof and mitral isthmus lines
- Primary Outcome Measures
Name Time Method Single procedural success rate (free from AF off anti-arrhythmic drugs) 12 MONTHS
- Secondary Outcome Measures
Name Time Method Percentage of AF termination Time 0 This information will be recorded immediately after the procedure.
recurrence of atrial fibrillation or organised atrial tachycardia 12 months after the last procedure Ablation time Time 0 This information will be recorded immediately after the procedure.
Procedure time Time 0 This information will be recorded immediately after the procedure
Multiple procedure success rate 12 months after last ablation Complication rate 30 days of procedure
Trial Locations
- Locations (2)
John Radcliffe Hospital
🇬🇧Oxford, United Kingdom
Royal Bournemouth Hospital
🇬🇧Bournemouth, United Kingdom