Interference of experimental pain and cognition in patients suffering from chronic pai

Not Applicable

Recruiting

• Conditions: M54; G43; Dorsalgia; Migraine

• Registration Number: DRKS00012448
• Lead Sponsor: niversitätsklinik Essen AöRKlinik für Neurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

(1) Age: 18 - 80
(2) voluntary, informed study participation
(3) chronic low back pain or chronic migraine (> 3 months; for migraine: attacks on > 15 days per month); healthy control subjects (matched to pain patients in age, gender, education)

Exclusion Criteria

(4) participation in other clinical trials testing medication
(5) severe depression or anxiety disorder
(6) pregnancy, nursing
(7) medication-overuse headache (MOH)
(8) other chronic pain conditions except lower back pain or migraine
(esp. radicular pain, neuropathic pain)
(9) intake of highly dosed opioids
(10) contraindication for MR testing, e.g.
• cardiac pacemaker and other magnetizable material within the body
• MR-incompatible metal material
• claustrophobia

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mean reaction times (ms) (categorisation task) and recognition performance (d prime, recollection and familiarity parameters) for images previously presented with electrical pain stimuli (1) at the lower back (L3-L5), (2) at the forehead (V1) or (3) without additional painful stimulation; Group comparison: (1) patients suffering from chronic lower back pain, (2) patients suffering from chronic migraine and (3) healthy control subjects. interaction effects: group x condition

Secondary Outcome Measures

Name	Time	Method
1) mean skin conductance response (amplitude, microsiemens; latency, ms) during painful stimulation and during the recognition task (for each experimental phase: main effect group, main effect stimulation, interaction group x stimulation) <br><br>2) Structural and functional predispositions (morphometry, resting state fMRI)