The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic
Phase 2
Completed
- Conditions
- Periodontal Pocket
- Registration Number
- NCT06669026
- Lead Sponsor
- Mansoura University
- Brief Summary
The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal therapy. By elucidating the molecular mechanisms underlying the therapeutic effects of vitamin D, this research seeks to contribute to the development of more effective treatment strategies for periodontitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Patients with attachment loss 3-4 mm
- periodontal pocket ≤ 5 mm
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Exclusion Criteria
-
- Patients with sensitivity to the medication used in the study.
- Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study.
- Patients with systemic diseases.
- Pregnant and lactating females.
- Smokers and tobacco chewers.
- Patients not compliant with oral hygiene procedures.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Primary Outcome Measures
Name Time Method Periodontal Assessment 12 weeks Periodontal Index
- Secondary Outcome Measures
Name Time Method Interleukin 8 8 weeks level of interleukin 8 in gingival crevicular fluid will be tested via elisa
alkaline phosphatase 8 weeks level of alkaline phosphatase in gingival crevicular fluid will be tested via elisa
Trial Locations
- Locations (1)
Alaaeldin Ahmed Taha
🇪🇬Cairo, Egypt