The role of the gut microbiome in the pathogenesis of IgA nephropathy

• Conditions: glomerulonephritis; IgA nephropathy; 10029149

• Registration Number: NL-OMON49937
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

Biopsy-proven
eGFR 15 - 90 ml/min/1.73m2
Age 18 - 70 years

Exclusion Criteria

No informed consent
Secondary causes of glomerular IgA depositions:
- Liver disease; cirrhosis, hepatitis B
- Gastro-intestinal disease; inflammatory bowel disease (IBD), celiac disease,
major gastro-intestinal surgery
- Skin disease; dermatitis herpetiformis, psoriasis
- Pulmonary disease
- Malignant disease
- Current infection
- IgA monoclonal gammopathy
- The use of immunosuppressive drugs
- Antibiotic treatment < 3 months
- CKD stage 5 / dialysis
- Pregnancy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Does the gastro-intestinal bacterial ecosystem between patients with IgA<br /><br>nephropathy differ from control renal patients and healthy controls? If so, in<br /><br>what way?</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Can disruption of the gastrointestinal bacterial ecosystem be linked to<br /><br>disease severity?<br /><br>2. Are there associations between health traits/dietary habits and the<br /><br>gastrointestinal bacterial ecosystem?</p><br>