Study of immunologic response after COVID-19 vaccination in kidney transplant recipients

Recruiting

• Conditions: Immune response after COVID-19 vaccination in immunosuppressed patients; Covid-19; vaccine; kidney transplant; immunosuppression

• Registration Number: TCTR20210611006
• Lead Sponsor: Ratchadapiseksompotch Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-11
• Study Completion: 2021-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

age > 18
- kidney transplant > 6 months

Exclusion Criteria

absolute lymphocyte count lower than 2,000 cells/microlitre
rejection with in 6 months
ABO incompatible kidney transplant
combined organ transplantation
previous kidney transplantation
eGFR (CKD-EPI) lower than 40 mL/min/1.73m2
Panel reactive antibody (PRA) > 20%
donor specific antibody positive
active hepatitis B, hepatitis C, HIV
poor controlled DM
poor controlled hypertension
poor controlled dyslipidemia
history of malignancy
history of BK virus nephropathy
history of CMV disease
pregnancy / lactation

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Immune response after complete vaccine 4 weeks after complete vaccination Neutralizing antibody and T-cell response

Secondary Outcome Measures

Name	Time	Method
Immune response after first dose 4 weeks after first dose Neutralizing antibody and T-cell response,Immune response after first dose 8 weeks after first dose Neutralizing antibody and T-cell response