Efficacy and safety of preemptive duloxetine and tramadol combination for the control of postoperative pain in patients undergoing unilateral total knee arthroplasty: A randomized, double-blind clinical trial - NI

AIIMS Bhubaneswar0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年5月27日

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•1. Patients both male and females undergoing unilateral total knee arthroplasty surgery.
•2. Patients who can provide informed consent
•3.Age group between 18-75 years

•1. Patients with chronic diseases including asthma, COPD, or any other respiratory disease.
•2. Persistent nausea and vomiting at the time of randomization
•3. History of seizure
•4. Subjects treated with monoamine oxidase inhibitors, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, gabapentinoids.
•5. Patient with known neurological/ neuropsychiatric disorders.
•6. Drug or alcohol abuse history
•7. Opioid tolerance or opioid dependence.
•8. Known history of opioid allergy or pregabalin allergy.
•9. Renal disease (creatinine >1.5mg/dl)
•10. Liver disease (total bilirubin = 1.5mg/dl, AST or ALT = 3 times ULN))
•11. Pregnancy and lactating women.
•12. Cardiovascular insufficiency.
•13. Patient with potential serotonin syndrome.
•14. Patient with a history of constipation and prone to paralytic ileus.

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