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Clinical Trials/CTRI/2023/07/055550
CTRI/2023/07/055550
Recruiting
Phase 4

Efficacy and safety of preemptive duloxetine and tramadol combination for the control of postoperative pain in patients undergoing unilateral total knee arthroplasty: A randomized, double-blind clinical trial - NI

AIIMS Bhubaneswar0 sites0 target enrollmentTBD
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ConditionsHealth Condition 1: - Health Condition 2: M171- Unilateral primary osteoarthritisof knee

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Health Condition 1: - Health Condition 2: M171- Unilateral primary osteoarthritisof knee
Sponsor
AIIMS Bhubaneswar
Status
Recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Interventional

Investigators

Eligibility Criteria

Inclusion Criteria

  • •1\. Patients both male and females undergoing unilateral total knee arthroplasty surgery.
  • •2\. Patients who can provide informed consent
  • •3\.Age group between 18\-75 years

Exclusion Criteria

  • •1\. Patients with chronic diseases including asthma, COPD, or any other respiratory disease.
  • •2\. Persistent nausea and vomiting at the time of randomization
  • •3\. History of seizure
  • •4\. Subjects treated with monoamine oxidase inhibitors, tricyclic antidepressants, serotonin\-norepinephrine reuptake inhibitors, gabapentinoids.
  • •5\. Patient with known neurological/ neuropsychiatric disorders.
  • •6\. Drug or alcohol abuse history
  • •7\. Opioid tolerance or opioid dependence.
  • •8\. Known history of opioid allergy or pregabalin allergy.
  • •9\. Renal disease (creatinine \>1\.5mg/dl)
  • •10\. Liver disease (total bilirubin \= 1\.5mg/dl, AST or ALT \= 3 times ULN))

Outcomes

Primary Outcomes

Not specified

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