Elimination of Albumin-Bound Substances by MARS and Prometheus

Not Applicable

Completed

• Conditions: Liver Failure

• Registration Number: NCT00407004
• Lead Sponsor: Medical University of Graz

Brief Summary

This trial compares the efficacy of two artificial liver support systems, MARS (Molecular Adsorbents Recirculating System) and Prometheus (FPSA, Fractionated Plasma Separation and Adsorption), in removing albumin-bound substances such as bilirubin, bile acids, and cytokines.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-03
• Study Completion: 2004-04
• Status Verified: 2006-11
• Study First Submitted: 2006-12-01
• Study First Submitted QC: 2006-12-01
• Last Update Submitted: 2006-12-01
• Study First Posted: 2006-12-04
• Last Update Posted: 2006-12-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• consecutive patients with acute-on-chronic liver failure (severe deterioration of chronic liver disease) unresponsive to standard medical treatment for >=48 hours

Exclusion Criteria

• arterial hypotension
• extrahepatic malignancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
serum levels of albumin-bound substances

Secondary Outcome Measures

Name	Time	Method
plasma clearance of albumin-bound substances

Trial Locations

Locations (1)

Medical University of Graz; 🇦🇹 Graz, Austria