Biologic Effects of DHEA in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- 6-month change in visceral and subcutaneous abdominal fat
研究概览
简要总结
The purpose of this study is to determine whether DHEA replacement therapy decreases abdominal fat and improves insulin sensitivity.
详细描述
Studies on rats and mice have shown that the adrenal hormone dehydroepiandrosterone (DHEA) reduces abdominal visceral fat and protects against insulin resistance. This study was done to learn if DHEA replacement therapy decreases abdominal obesity and improves insulin action in humans.
Participants were randomly assigned to receive 50 mg per day of DHEA or a placebo at bedtime for 6 months. Participants underwent magnetic resonance imaging (MRI) and oral glucose tolerance tests at the beginning and conclusion of the study. Other tests included measurements of hormones and lipids.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Prevention
- 盲法
- Double
入排标准
- 年龄范围
- 65 Years 至 78 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •65 to 78 years old
- •Physically healthy
- •Non-smoker
- •On stable medications for at least 6 months
- •Stable body weight for the past year
排除标准
- •Serious active medical problems
- •Hormone therapy
- •Abnormal PSA (prostate specific antigen) in men
结局指标
主要结局
6-month change in visceral and subcutaneous abdominal fat
次要结局
未报告次要终点