Evaluation of the Interference of Antithrombotic Agents With Laboratory Monitoring of Heparin Therapy
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Correlation between the plasmatic concentration in direct oral anticoagulants (DOAC) or International Normalized Ratio for AVK and the value of the Activated clotting time (ACT)
研究概览
简要总结
Oral anticoagulants are increasingly prescribed and the are not discontinued for invasive cardiac procedures .
Additional parenteral anticoagulation is necessary for these procedures (FA ablation and invasive coronary explorations).
The unfractionated heparin doses are adapted on a monitoring test heparin, activated clotting time (ACT) with the aim of obtaining and maintaining an ACT > 300-400 sec. This goal is the same whether the patient is on oral anticoagulant treatment or not, and regardless of the initial level of anticoagulation.
The effects of oral anticoagulants on routine coagulation tests (PT, APTT, TT) are well documented, but few data have been published on the effects of heparin monitoring tests, particularly on the ACT.
The aim of this stuy is to redefine the target values of ACT and unfractionated heparin doses to administer to optimize the efficacy / safety of invasive procedures in cardiology.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient treated with oral anticoagulant at curative dose and requiring a requiring a venous blood sample for his management
排除标准
- •opposition to the patient to participate to the study
结局指标
主要结局
Correlation between the plasmatic concentration in direct oral anticoagulants (DOAC) or International Normalized Ratio for AVK and the value of the Activated clotting time (ACT)
时间窗: 1 hour
次要结局
未报告次要终点