Diyabetik Hipertansif Hastalarda Stres Yanıtının Değerlendirilmesi
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Cortisol
研究概览
简要总结
In this research, we aimed to examine salivary cortisol changes in the cognitive stress response of patients with Hypertension + Diabetes Mellitus (HT+DM) and Hypertension (HT) and to determine the differences between them.
The research was conducted by solving an arithmetic task as a stress test in 62 patients with HT+DM and HT that are being treated in the outpatient clinic of Medical Pharmacology and Clinical Pharmacology Department at Istanbul University, Istanbul Medical Faculty Hospital.
详细描述
In this study, saliva samples were taken for cortisol measurement, and patients were instructed to place the cotton piece in the salivette® tubes directly into their mouths without touching it with anything, hold it for 30-60 seconds, and then insert it back into the tubes in the same way, four times total, once before arithmetic stress and three times after stress, on Tuesdays, Wednesdays, and Thursdays between the hours of 12:00-16:00.
Salivary cortisol was measured using the electro-chemiluminescence immunoassay.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Using antihypertensive treatment for the last 3 months
- •Diagnosed with Type 2 Diabetes Mellitus and taking medication for at least 3 months
- •Being between the ages of 40-65
- •Having signed the informed consent form
排除标准
- •Female gender
- •Patients younger than 40 years old or older than 65 years old
- •Uncontrolled blood pressure (SBP>140 mmHg, DBP>90 mmHg)
- •Using antipsychotic medication
- •Using current treatment for less than 3 months
- •Having a previous MI
- •Having a previous stroke
- •Having a lung disease
- •Having organ failure
- •Having Cushing's disease
- •Having aldosteronism
- •Failure to sign the informed consent form
结局指标
主要结局
Cortisol
时间窗: 60 minutes after beginning
A saliva sample is collected
Blood pressure
时间窗: 75 minutes after beginning measurement
The patient is rested by sitting before the measurement
Aldosterone
时间窗: Baseline
Venous blood sample is collected
Heart Rate
时间窗: 75 minutes after beginning
The patient is rested by sitting before the measurement
次要结局
- Physical activity(Baseline)
- Mental state examination(Baseline)
- Health related Quality of life(Baseline)
研究者
Iliriana Alloqi Tahirbegolli
Principal investigator
Istanbul University