Resting Heart Rate in Chronic Obstructive Pulmonary Disease

Not Applicable

Completed

• Conditions: COPD; Pulmonary Rehabilitation; Exercise; Resting Heart Rate
• Interventions: Other: Pulmonary Rehabilitation

• Registration Number: NCT04890080
• Lead Sponsor: Izmir Katip Celebi University

Brief Summary

110 COPD patients who were participated in the PR program were included in the study. Resting Heart Rate , pulmonary functions, functional capacity, perception of dyspnea, quality of life and psychological symptoms compared before and after PR.

Detailed Description

In many studies, it has been reported that baroreceptor activity and heart rate variability decrease and resting heart rate (RHR) increases in COPD patients due to changes in cardiac autonomic function. Among the recommendations regarding pulmonary rehabilitation (PR) and exercise training in COPD patients, approaches such as including practices targeting RHR and developing implementation strategies that improve the cardiovascular system are recommended. The primary aim of our study is to examine the effect of comprehensive exercise training consisting of breathing, aerobic and strengthening exercises on RHR in COPD patients, and secondarily to determine the factors that affect RHR change after PR in COPD patients.

110 COPD patients who were participated in the PR program were included in our retrospective study. Resting Heart Rate , pulmonary functions, functional capacity, perception of dyspnea, quality of life and psychological symptoms compared before and after PR.

Study Timeline

• Study Start: 2017-01
• Primary Completion: 2019-12
• Study Completion: 2021-04
• Status Verified: 2021-05
• Study First Submitted: 2021-05-12
• Study First Submitted QC: 2021-05-12
• Last Update Submitted: 2021-05-12
• Study First Posted: 2021-05-18
• Last Update Posted: 2021-05-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• Patients diagnosed with COPD according to GOLD and completed the 2-day / 8-week PR program

Exclusion Criteria

• With cardiovascular disease
• With additional diseases such as diabetes
• Receiving medical treatment that affects the autonomic nervous system
• Patients receiving long-term oxygen therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
PR Group	Pulmonary Rehabilitation	Patients diagnosed with COPD according to GOLD and completed the 2-day / 8-week PR program

Primary Outcome Measures

Name	Time	Method
Resting Heart Rate	1 minute	number of beats per minute

Secondary Outcome Measures

Name	Time	Method
Functional Capacity	Change from baseline six minute walk distance at 8 week	Six Minute- walk test
Dyspnea Assessment	Change from baseline dyspnea at 8 week	Medical Research Council Scale(MRC); the MRC dyspnea scale is a questionnaire that consists of five statements about perceived breathlessness. (min 1- max 5 point) Higher scores mean a worse outcome.
Quality of Life Assessment	Change from baseline dyspnea at 8 week	St. George Respiratory Questionnaire; Scores range from 0 to 100, with higher scores indicating more limitations.
Anxiety and Depression	Change from baseline dyspnea at 8 week	Hospital Anxiety and Depression (HAD); The HADS questionnaire has seven items each for depression and anxiety subscales. Scoring for each item ranges from zero to three, with three denoting highest anxiety or depression level. A total subscale score of \>8 points out of a possible 21 denotes considerable symptoms of anxiety or depression.