A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin

Not Applicable

Completed

• Conditions: Verruca Vulgaris
• Interventions: Drug: Liquid nitrogen and cantharidin; Drug: Liquid nitrogen and topical placebo

• Registration Number: NCT01084824
• Lead Sponsor: North Idaho Dermatology

Brief Summary

The purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used for warts (verruca vulgaris).

Detailed Description

Not available

Study Timeline

• Study Start: 2007-06
• Primary Completion: 2008-06
• Study Completion: 2008-09
• Status Verified: 2010-03
• Study First Submitted: 2010-03-10
• Study First Submitted QC: 2010-03-10
• Last Update Submitted: 2010-03-10
• Study First Posted: 2010-03-11
• Last Update Posted: 2010-03-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

1. common warts on non-genital, non-facial skin
2. otherwise healthy
3. between 18-65 and able to give informed consent
4. capable of tolerating treatment

Exclusion Criteria

1. Ill-health
2. Poor tolerance or sensitivity to treatments in study
3. <18 years old; >65 years old
4. verruca plana or condyloma acuminata
5. immunosuppression or immune dysfunction
6. significant peripheral vascular disease
7. significant sensitivity to cold
8. epidermodysplasia verruciformis
9. mosaiform warts or periungual warts

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Liquid nitrogen and canthardin	Liquid nitrogen and cantharidin	Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterwards.
Liquid nitrogen and placebo	Liquid nitrogen and topical placebo	Liquid nitrogen applied to wart(s) then placebo vehicle afterwards.

Primary Outcome Measures

Name	Time	Method
Percentage of common warts cleared	12 weeks	Percentage of treated warts cleared with treatment, as measured with dermatoscopic examination, after 12 weeks.

Trial Locations

Locations (1)

North Idaho Dermatology; 🇺🇸 Coeur D'Alene, Idaho, United States