Pain in PASC - the Role of Sleep Disturbances
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Pain sensitivity
研究概览
简要总结
Pain is among the most frequently reported symptoms in Long COVID, along with sleep disturbances, fatigue, and cognitive impairments. Sleep plays a critical role in maintaining a pain-free state. The goal of this study is to characterize the type and severity of pain in Long COVID, to characterize sleep and sleep disturbances in Long COVID, and to understand the role of sleep in the development and persistence of pain symptoms in Long COVID.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Females and males >18 years
- •Confirmed history of SARS-CoV-2 infection
- •Exclusion Criteria
- •History of chronic pain prior to SARS-CoV-2 infection
- •Raynaud syndrome
- •Pregnant/nursing
排除标准
- 未提供
结局指标
主要结局
Pain sensitivity
时间窗: 1 day
Pain thresholds to mechanical and temperature stimuli measured in kPa (pressure) and Celsius (heat). Lower values indicate lower pain thresholds.
Wearable based sleep characteristics
时间窗: 2 weeks
Estimation of sleep duration, fragmentation, regularity based on actigraphy
PSG based sleep characteristics
时间窗: 1 day
Sleep stages and architecture based on PSG
Central pain modulation
时间窗: 1 day
Capacity of the CNS to modulate pain
Pain reporting
时间窗: 14 days
Daily pain severity reporting on rating scale from 0 to 10 (greater values indicate greater pain)
次要结局
未报告次要终点
研究者
Monika Haack
Associate Professor of Neurology
Beth Israel Deaconess Medical Center