Pain in Long COVID-19: the Role of Sleep

Active, not recruiting

• Conditions: Long COVID
• Interventions: Other: No intervention

• Registration Number: NCT05606211
• Lead Sponsor: Beth Israel Deaconess Medical Center

Brief Summary

Pain is among the most frequently reported symptoms in Long COVID, along with sleep disturbances, fatigue, and cognitive impairments. Sleep plays a critical role in maintaining a pain-free state. The goal of this study is to characterize the type and severity of pain in Long COVID, to characterize sleep and sleep disturbances in Long COVID, and to understand the role of sleep in the development and persistence of pain symptoms in Long COVID.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-04
• Study First Submitted: 2022-11-02
• Study First Submitted QC: 2022-11-02
• Study First Posted: 2022-11-04
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-20
• Last Update Posted: 2025-03-24
• Primary Completion: 2025-12-30
• Study Completion: 2025-12-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Females and males >18 years
• Confirmed history of SARS-CoV-2 infection

Exclusion Criteria

• History of chronic pain prior to SARS-CoV-2 infection
• Raynaud syndrome
• Pregnant/nursing

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
No Long COVID	No intervention	Individuals who have been infected with the corona virus and fully recovered.
Long COVID	No intervention	Individuals who have been infected with the corona virus and developed Long COVID

Primary Outcome Measures

Name	Time	Method
Pain sensitivity	1 day	Pain thresholds to mechanical and temperature stimuli measured in kPa (pressure) and Celsius (heat). Lower values indicate lower pain thresholds.
Wearable based sleep characteristics	2 weeks	Estimation of sleep duration, fragmentation, regularity based on actigraphy
PSG based sleep characteristics	1 day	Sleep stages and architecture based on PSG
Central pain modulation	1 day	Capacity of the CNS to modulate pain
Pain reporting	14 days	Daily pain severity reporting on rating scale from 0 to 10 (greater values indicate greater pain)

Trial Locations

Locations (1)

Beth Israel Deaconess Medical Center; 🇺🇸 Boston, Massachusetts, United States