Retinal Artery Study in participants with obstructive sleep apnoea treated with continuous positive airway pressure

Not Applicable

Completed

• Conditions: Sleep Apnoea; Endothelial function; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Respiratory - Sleep apnoea

• Registration Number: ACTRN12610000311055
• Lead Sponsor: Austin Health Department of Cardiology and Institute for Breathing and Sleep

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-04-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Moderate to severe Obstructive Sleep Apnoea(OSA) - Apnoea Hypopnoea Index greater than or equal to 30, with associated hypoxaemia – Oxygen saturation(Sa O2) <90% for a minimumm of 6% of total sleep time.
Actual coronary artery disease or two or more of the following cardiovascular risk factors – hypertension, dyslipidaemia, diabetes, smoking, positive family history.

Exclusion Criteria

Commercial driver or patients listed for urgent CPAP implementation.
Glaucoma

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The Dynamic Vessel Analyzer (IMEDOS, Germany) is used to measure retinal vascular endothelial function. Changes in ocular haemodynamic parameters expressed as the percentage change over baseline values in response to flicker light stimulation.[After 6 weeks of treatment with CPAP or no CPAP]

Secondary Outcome Measures

Name	Time	Method
il[Nil]