Comparison of systematic treatment algorithms with treatment as usual in patients with unipolar depressio

Phase 4

• Conditions: F32; F33; Depressive episode; Recurrent depressive disorder

• Registration Number: DRKS00000161
• Lead Sponsor: Charité Universitätsmedizin Berlin, Campus Charité Mitte

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2005-09-30
• Study Start: 2009-07-23
• Results First Posted: 2017-06-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 475

Inclusion Criteria

major depressive episode, with or wíthout psychotic symtoms (ICD-10: F32.0, F32.1, F32.2, F32.3)
recurrent depressive disorder, with or without psychotic symptoms (ICD-10: F33.0, F33.1, F33.2, F33.3, F33.8, F33.9)
HAMD-score > 15
age 18-70 years
informed consent

Exclusion Criteria

bipolar affective disorder (ICD-10: F31)
depression caused by another medical condition,
pregnancy/breastfeeding,
pre-existing long-term medication treatment that could not be discontinued
severe medical condition which presented a limitation for any of the possible treatments in the study
admission by court order

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
time to remission (HAMD-21 < = 9 Punkte)<br>HAMD: Hamilton Depression Rating Scale

Secondary Outcome Measures

Name	Time	Method
- time to response (HAMD-reduction > 50%)<br>- number of remitted patients (HAMD-21 < = 9)<br>- number of patients who achieved response (HAMD-Reduktion > 50%)<br>- number of strategy changes (switches)<br>- duration of inpatient treatment<br>- direct and indirect costs