The Protective Effect of Prostaglandin on Coronary Microcirculation and Ventricular Remodeling After Reperfusion Therapy in Acute ST-segment Elevation Myocardial Infarction

Phase 1

• Conditions: STEMI
• Interventions: Drug: beprostaglandin sodium

• Registration Number: NCT05043558
• Lead Sponsor: Shenzhen People's Hospital

Brief Summary

To explore the protective effect of prostaglandin sodium on coronary microcirculation function and ventricular remodeling after reperfusion treatment of acute ST-segment elevation myocardial infarction.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-08
• Study First Submitted: 2021-08-25
• Study First Submitted QC: 2021-09-04
• Last Update Submitted: 2021-09-04
• Study First Posted: 2021-09-14
• Last Update Posted: 2021-09-14
• Study Start: 2022-01-01
• Primary Completion: 2022-01-10
• Study Completion: 2022-01-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

• 1. Meet the diagnostic criteria for acute ST-segment elevation myocardial infarction: ①The onset of ischemic chest pain lasts for more than 30 minutes and cannot be relieved by taking nitroglycerin; ②The ECG has two or more ST-segment elevations in adjacent leads , Limb leads ≥ 1mm, pectoral leads ≥ 2mm; or newly-appearing left bundle branch block; ③The increase in serum markers of myocardial necrosis is at least twice the normal value; (2) Coronary angiography confirmed acute myocardial infarction; (3) Direct PCI treatment within 12 hours of onset; (4) Complete clinical and radiographic data.

Exclusion Criteria

• (1) Those who do not cooperate in the inspection, have poor compliance, and cannot guarantee the completion of the test; (2) Persons with consciousness impairment, obvious intellectual impairment and mental abnormality; (3) With metal foreign bodies, such as metal prostheses, intraocular metal foreign bodies, intracranial aneurysm clamps, etc.; (4) Those who suffer from closure phobia; (5) Those who have had a history of myocardial infarction, PCI treatment, or coronary artery bypass graft; (6) Factors affecting the changes in the ST segment of the electrocardiogram: complete left bundle branch block, pre-excitation syndrome, pacemaker electrocardiogram

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
beprostaglandin sodium	beprostaglandin sodium	-

Primary Outcome Measures

Name	Time	Method
ultrasound and CMR to assess the characteristics of myocardial infarction	3 years	Q-LAB Scale Scale calculation score

Trial Locations

Locations (1)

Shenzhen People' S Hospital; 🇨🇳 Shenzhen, Guangdong, China