NCT05043558Unknown1 期
The Protective Effect of Prostaglandin on Coronary Microcirculation and Ventricular Remodeling After Reperfusion Therapy in Acute ST-segment Elevation Myocardial Infarction
Shenzhen People's Hospital1 个研究点 分布在 1 个国家目标入组 220 人开始时间: 2022年1月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 220
- 试验地点
- 1
- 主要终点
- ultrasound and CMR to assess the characteristics of myocardial infarction
研究概览
简要总结
To explore the protective effect of prostaglandin sodium on coronary microcirculation function and ventricular remodeling after reperfusion treatment of acute ST-segment elevation myocardial infarction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meet the diagnostic criteria for acute ST-segment elevation myocardial infarction: ①The onset of ischemic chest pain lasts for more than 30 minutes and cannot be relieved by taking nitroglycerin; ②The ECG has two or more ST-segment elevations in adjacent leads , Limb leads ≥ 1mm, pectoral leads ≥ 2mm; or newly-appearing left bundle branch block; ③The increase in serum markers of myocardial necrosis is at least twice the normal value; (2) Coronary angiography confirmed acute myocardial infarction; (3) Direct PCI treatment within 12 hours of onset; (4) Complete clinical and radiographic data.
排除标准
- •(1) Those who do not cooperate in the inspection, have poor compliance, and cannot guarantee the completion of the test; (2) Persons with consciousness impairment, obvious intellectual impairment and mental abnormality; (3) With metal foreign bodies, such as metal prostheses, intraocular metal foreign bodies, intracranial aneurysm clamps, etc.; (4) Those who suffer from closure phobia; (5) Those who have had a history of myocardial infarction, PCI treatment, or coronary artery bypass graft; (6) Factors affecting the changes in the ST segment of the electrocardiogram: complete left bundle branch block, pre-excitation syndrome, pacemaker electrocardiogram
研究组 & 干预措施
beprostaglandin sodium
Experimental
干预措施: beprostaglandin sodium (Drug)
结局指标
主要结局
ultrasound and CMR to assess the characteristics of myocardial infarction
时间窗: 3 years
Q-LAB Scale Scale calculation score
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
3 期
Vasoactive and Anti-inflammatory Effects of Prasugrel in Acute Coronary SyndromeAcute Coronary SyndromeUnstable AnginaNCT01774838University of Cologne49
进行中（未招募）
1 期
Protective effect of antiplatelet drug Ticagrelor compared to antiplatelet drug Clopidogrel on small heart vessels in diabetic patient with anginaIschemic Heart Disease in Diabetic patientsMedDRA version: 18.1 Level: PT Classification code 10072685 Term: Microvascular coronary artery disease System Organ Class: 10007541 - Cardiac disordersEUCTR2015-003621-33-ESFundación Interhospitalaria de Investigación Cardiovascular50
已完成
不适用
Coronary Microcirculatory and Bioresorbable Vascular ScaffoldsCHD - Coronary Heart DiseaseAngina, StableMyocardial IschemiaNCT03076476Papworth Hospital NHS Foundation Trust36
已完成
不适用
Impact of Ranolazine on Coronary Microcirculatory ResistanceCoronary MicrocirculationMyocardial DiseaseIschemiaCoronary Artery DiseaseNCT01815957University of New Mexico7
招募中
不适用
Study of Microvascular Dysfunction, CFR and Cardioprotective Effect of Early Administration of Esmolol in MICoronary StenosisMyocardial InfarctionCoronary Microvascular DysfunctionNCT06376630National Medical Research Center for Cardiology, Ministry of Health of Russian Federation300