The effect of Magnesium Oxide on Improvement of Carotid intima media Thickness in hemodialysis patients

Phase 2

• Conditions: End Stage Renal Disease.; End stage renal disease

• Registration Number: IRCT138808202370N4
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

Inclusions:
1- Age >= 18
2- Not having class IV heart failure
3- No history of CABG
4- No history of recent chemotherapy for malignancy
5- Serum PTH > 100
6- Serum Mg > 1.6 < 4 mg/dl
7- Not consuming drugs containing Mg, Ca Chanel Blockers, Chalsiteriol, during 3 months before study
8- Patients with ESRD on maintenance hemodialysis (> 3 mo)
9- Not having uncontrolled HTN
10- Not being in transplantation schedule in the following 6 months

Exclusions:
1- No compliance
2- Severe side effects
3- Serum Mg > 4 mg/dl
4- Transplantation

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Carotid Intima Media Thickness. Timepoint: Before & After Intervention. Method of measurement: Ultrasound Scan.

Secondary Outcome Measures

Name	Time	Method
Serum Ca. Timepoint: Before & After Intervention. Method of measurement: Autoanalyser.;Serum phsphorus. Timepoint: Before & After Intervention. Method of measurement: Autoanalyser.;Serum albumin. Timepoint: Before & After Intervention. Method of measurement: Autoanalyser.;Serum PTH. Timepoint: Before & After Intervention. Method of measurement: Gama Counter.;Serum magnesium. Timepoint: Before, monthly & After Intervention. Method of measurement: Autoanalyser.;Serum TG. Timepoint: Before & After Intervention. Method of measurement: Autoanalyser.;Serum total cholestrol. Timepoint: Before & After Intervention. Method of measurement: Autoanalyser.;Serum HDL. Timepoint: Before & After Intervention. Method of measurement: Autoanalyser.;Serum LDL. Timepoint: Before & After Intervention. Method of measurement: Autoanalyser.;Serum bicarbonate. Timepoint: Before & After Intervention. Method of measurement: Autoanalyser.;Serum CRP. Timepoint: befoe & after intervention. Method of measurement: ELISA.