Comparison Study of Operation and PEIT for Small, Solitary Hepatocellular Carcinoma (HCC)
Not Applicable
Completed
- Conditions
- Hepatocellular Carcinoma
- Interventions
- Procedure: Percutaneous ethanol injection therapyProcedure: Operation
- Registration Number
- NCT00357422
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The purpose of this study is to choose the preferred treatment modality for solitary, small hepatocellular carcinoma.
- Detailed Description
To compare the below things between operation group and percutaneous ethanol injection therapy (PEIT) group:
1. Survival
* 5 year overall survival rate
* Disease free survival rate
2. Recurrence
* Cumulative recurrence rate
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
- The evidences of hepatitis B virus (HBV)&/or hepatitis C virus (HCV) infection or liver cirrhosis
- Single tumor nodule with Child-Pugh classification A (serum albumin ≥ 3.2 g/dL)
- The maximal, longest diameter of tumor mass measured by CT finding should be less than 2 cm
- Only for the newly detected HCCs which were not treated before
- It should be compatible with the typical finding of hepatocellular carcinomas (HCCs) radiologically (MD CT or dynamic MRI)
- Without portal hypertension
Exclusion Criteria
- In case of hepatic vein or portal vein invasion radiologically (CT or MRI)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description local therapy Percutaneous ethanol injection therapy - surgery Operation -
- Primary Outcome Measures
Name Time Method overall survival rate 5 year
- Secondary Outcome Measures
Name Time Method disease free survival rate and recurrence rate 5 year
Trial Locations
- Locations (1)
Seoul NUH
🇰🇷Seoul, Chongno-gu, Korea, Republic of