IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing
Not Applicable
Completed
- Conditions
- Infertility
- Interventions
- Procedure: embryo freezingProcedure: oocyte vitrification
- Registration Number
- NCT02026193
- Lead Sponsor
- Rambam Health Care Campus
- Brief Summary
The chances to achieve pregnancy after retrieving \>15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining). Therefore, in most such cases the investigators prefer to freeze all embryos, and transfer in a thaw cycle. With the introduction of oocyte vitrification (very fast cooling) technology, a new option emerged: to freeze un-fertilized eggs, to be fertilized and used later in a thaw cycle.
The purpose of this study is to compare the outcome of these two approaches.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 11
Inclusion Criteria
- IVF patients
- ovulation trigger with Decapeptyl 0.2 mg because of ovarian hyper-response: E2 on trigger day .12,000 pmol/l and/or >15 oocytes.
- Normal uterus
Exclusion Criteria
- <20% fertilization rate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description embryo freezing embryo freezing All retrieved oocytes will be fertilized, and resulting embryos will be frozen. oocyte vitrification oocyte vitrification All retrieved mature oocytes will be vitrified.
- Primary Outcome Measures
Name Time Method Fetal Heart Activity 1 Month Post Embryo Transfer 1 month after embryo transfer Fetal heart activity as demonsrated by vaginal ultrasound 1 month post embryo transfer
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
IVF Unit, Rambam medical Center
🇮🇱Haifa, Israel