Evaluating the Influence of Day-to-day Blood Pressure Variation in Acute Ischemic Stroke on Adverse Outcomes in Long-term Post-stroke Followup
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Zhu Shi
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- mortality
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Stroke is one of the most devastating disorder worldwide. Hypertension has been confirmed to be a major modifiable risk factor for stroke.Even the casual visit hypertension has been managed ideally,there is still surplus risk for stroke re-attack.The purpose of this study is to explore whether variation of 24-hour ambulatory and visit-to-visit blood pressure variability (BPV) contribute to recurrent stroke.
Detailed Description
System hypertension has been reported to play the most important role in the development of stroke,and the anti-hypertension therapy is regarded as the cornerstone for stroke secondary prevention. However, even though some proper measures have been taken,there is still surplus risk for recurrent stroke. Recently the variation of system blood pressure has been focused as the candidate of another risk factor.Up to date,this hypothesis remains an intense debate and few studies has been done to clarify it.Besides, the definition of BPV and measurement of BPV parameters are still beyond conformity.In the current study, the long-term and short-term BPV will be taken respectively for patients with prior stroke. Bsed on these parameters, the cohort will be followed up for average 2 years. The predefined outcome include composite cardiovascular events, neuropsychiatric wording, and mortality during followup.
Investigators
Zhu Shi
deputy director of neurology department
Dongguan People's Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •comorbidity of dementia ( including AD, PDD, FTLD, VaD and so on )
- •coexisting severe systematic diseases on admission such as acute coronary syndrome, malignant tumor, plasma dialysis therapy for renal failure, cirrhosis, rheumatic disease that would influence mortality.
- •discharge with severe sequelae with mRS\>5
Outcomes
Primary Outcomes
mortality
Time Frame: 12 months
all cause death
Secondary Outcomes
- microvascular events(12 months)
- macrovascular events(12 months)