NCT01571609CompletedNot Applicable
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Aarhus
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- insulin secretion
Study Overview
Brief Summary
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18-70 years of age
- •Member of Biobank Vejle
Exclusion Criteria
- •Diabetes mellitus
- •Severe illness
Arms & Interventions
Carriers
Experimental
Intervention: first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer (Other)
Non-carriers
Experimental
Intervention: first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer (Other)
Outcomes
Primary Outcomes
insulin secretion
Time Frame: 10 minutes
Estimation of first phase insulin secretion
Secondary Outcomes
- Insulin resistance(60 minutes)
- body composition(60 minutes)
- atherosclerosis(30 minutes)
- biochemical blood profiling(at baseline)
- Blood pressure(24 hours)
- Indirect calorimetry(60 minutes)
- Insulin resistance(240 minutes)
Investigators
Julie Støy
MD
University of Aarhus
Study Sites (1)
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