Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

Phase 2

Recruiting

• Conditions: Moderately to Severely Active Crohn Disease
• Interventions: Other: Placebo; Drug: Obefazimod

• Registration Number: NCT06456593
• Lead Sponsor: Abivax S.A.

Brief Summary

This study has 3 treatment phases, a 12-Week Induction Phase, a 40-Week Maintenance Phase, and a 48-Week Extension Phase.

The objective is to evaluate the efficacy and safety of obefazimod compared to placebo as induction and maintenance therapy in subjects with moderately to severely active CD after inadequate response (no response, loss of response, or intolerance) to conventional therapies and/or advanced therapies.

The primary objective for the 48-Week Extension Phase is to evaluate the safety and tolerability of obefazimod compared with placebo in subjects who are enrolled in the Extension Phase.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-05-16
• Study First Submitted QC: 2024-06-07
• Study First Posted: 2024-06-13
• Study Start: 2024-10-30
• Status Verified: 2025-04
• Last Update Submitted: 2025-05-19
• Last Update Posted: 2025-05-20
• Primary Completion: 2026-12
• Study Completion: 2028-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 212

Inclusion Criteria

1. Male or female (at birth) 18 to 75 years old and able to understand, sign, and date the written voluntary informed consent at the visit prior to any protocol-specified procedures
2. Able and willing to comply with study visits and procedures as per protocol.
3. Confirmed and documented diagnosis of CD based on endoscopy and histology reports.
4. Moderately to severely active CD as defined by 220 ≤ CDAI ≤ 450 and SES-CD ≥ 6 for ileo-colonic or colonic disease or SES-CD ≥ 4 for isolated ileal disease (per central reading).
5. Documented inadequate response (defined as lack of response or loss of response or intolerance) to at least one of the following treatments: corticosteroids (CS), immunosuppressants (IS), biologic or biosimilar therapies, or janus kinase (JAK) (note: failure to only 5-aminosalicylic acid [5-ASA] is not accepted)
6. Women of childbearing potential (WOCBP) and male subjects with WOCBP partner must agree to comply with contraception requirements as stated in section 4.5 (contraception) of this protocol.
7. Subject should be affiliated to a health insurance policy whenever required by a participating country or state.
8. Subject is able and willing to comply with usual public recommendations for sun protection.

Exclusion Criteria

Subjects who meet any of the following exclusion criteria will be excluded from the study:

1. WOCBP subject who is pregnant or breast-feeding at screening, or intends to become pregnant during the study; or male subject with WOCBP partner who intends to be pregnant during the study.

2. Current diagnosis of ulcerative colitis (UC) or indeterminate colitis

3. CD without ileal and/or colonic involvement

4. Untreated active external or perianal fistula or abscess. Stable fistula without abscess and with minimal or low drainage may be enrolled. Recent cutaneous and perianal abscesses are not exclusionary if drained and adequately treated at least 3 weeks before screening colonoscopy or 8 weeks before screening colonoscopy for intra-abdominal abscesses, if no additional surgery is anticipated.

5. Symptomatic bowel stricture and/or stenosis not passable in endoscopy

6. Related to CD surgery:

   1. Current stoma or ileoanal pouch
   2. More than 2 missing complete segments of the following 5 segments: terminal ileum, right colon, transverse colon, left colon, and sigmoid and rectum
   3. Combined previous small bowel resections > 100 cm
   4. Surgical bowel resection within the past 3 months prior to baseline
   5. Any other manifestation that might require surgery while enrolled in the study

7. Related to CD treatments:

   1. Subject who is currently treated with prohibited concomitant therapies for CD as described in the study protocol
   2. Subject who has previously received natalizumab (or any other α4β1 integrin agonist)
   3. Subject who has failed more than three advanced therapies for the treatment of CD, or two different mechanisms of action for advanced therapies of CD

8. History of, or active, malignancy including nonmelanoma skin cancer (subjects with a 5-year disease-free survival are eligible)

9. History of colonic cancer or colonic low grade or high grade dysplasia adenomatous polyps, and/or at the screening endoscopy, evidence of low grade or high grade dysplasia adenomatous polyps (fully removed or not)

10. Subject with history of, or diagnosed with, the following during screening: primary sclerosing cholangitis, autoimmune hepatitis, or primary biliary cirrhosis

11. Serious illness requiring hospitalization (not related to CD) within 4 weeks prior to screening

12. Subject with the following infectious conditions:

    1. Chronic or recurrent Grade 3 or Grade 4 infection within the last 2 months prior to screening or history of opportunistic infection while not on immunosuppressive therapy
    2. Herpes zoster reactivation within the last 2 months prior to screening
    3. Active infection at screening or any major episode of infection that required hospitalization or treatment with IV antibiotics within 1 month of screening or during screening (fungal infection of nail beds is allowed)
    4. Positive assay or stool culture for pathogens (ova and parasite examination, bacteria) that required treatment per local medical practice or positive test for Clostridioides difficile (C. difficile) toxin at screening.
    5. Subject with human immunodeficiency virus (HIV) infection
    6. Acute or chronic hepatitis B infection at screening (positive for hepatitis B surface antigen [HbsAg] or negative for HbsAg and positive for anti-hepatitis B core antibody in conjunction with detectable hepatitis B virus [HBV] deoxyribonucleic acid [DNA], or detectable HBV DNA).
    7. Acute or chronic hepatitis C virus (HCV) infection as defined by positive for hepatitis C antibody (subjects successfully treated and without recurrence ≥ 1 year with no detectable HCV RNA [assessed centrally] are eligible)
    8. Active tuberculosis (TB) or untreated latent TB (For subjects with positive or intermediate QuantiFERON test)

13. Subject with uncontrolled ischemic heart disease and/or a history of congestive heart failure

14. Subject with a known family or personal history of congenital or acquired long QT syndrome, or subjects with a marked baseline prolongation of QT/ heart rate-corrected QT (QTc) interval

15. Subject with a history of torsade de pointe (TdP)

16. Acute or chronic clinically relevant pulmonary, hepatic, or renal functional abnormality, encephalopathy, neuropathy or unstable central nervous system pathology such as seizure disorder, or any other clinically significant medical problems.

17. Subjects who received live vaccine within 3 months prior to screening and/or subject who is planning to receive such a vaccine during the study duration

18. Acute or chronic pancreatitis

19. Subject with the following hematological and biochemical laboratory parameters obtained during the screening period:

    1. Hemoglobin ≤ 8.0 g/dL1
    2. Absolute neutrophil count < 750/mm3
    3. Platelets < 100,000 /mm3
    4. eGFR < 60 mL/min/1.73 m2
    5. Total serum bilirubin > 1.5 x ULN (except if related to pre-existing and documented Gilbert syndrome)
    6. Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 2 x ULN

20. Subject who does not meet the washout period requirements prior to the screening endoscopy as described in the prohibited medication section of the study protocol

21. Use of any investigational or nonregistered product within 3 months or within 5 halflives preceding baseline, whichever is longer, and during the study.

22. Subjects previously treated with obefazimod or with a known hypersensitivity to the active substance or to any of the excipients

23. Illicit drug or alcohol abuse or dependence

24. Subject who is committed to an institution by virtue of an order issued either by the judicial or the administrative authorities

25. Any condition, which in the opinion of the investigator, could compromise the subject's safety or adherence to the study protocol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Placebo given once-daily (QD) in subjects with moderately to severely active Crohn's disease (CD)
Obefazimod 25mg	Obefazimod	Obefazimod 25mg given once-daily (QD) in subjects with moderately to severely active Crohn's disease (CD)
Obefazimod 50mg	Obefazimod	Obefazimod 50mg given once-daily (QD) in subjects with moderately to severely active Crohn's disease (CD)
Obefazimod 12.5mg	Obefazimod	Obefazimod 12.5mg given once-daily (QD) in subjects with moderately to severely active Crohn's disease (CD)

Primary Outcome Measures

Name	Time	Method
Maintenance Phase Efficacy - Simple Endoscopic Score for Crohn's disease (SES-CD)	Week 52	Change from baseline in Simple Endoscopic Score for Crohn's disease (SES-CD) at Week 52; The SES-CD is an endoscopic grading system that consists of a composite score based on 4 components: the size of mucosal ulcers, the extent of the ulcerated surface, the endoscopic extension, and the presence of stenosis (26). Each of the 4 SES-CD components are assessed in the 5 segments of the ileum and colon: ileum, right, transverse, left, and rectum. The SES-CD is the sum of the individual scores of each of the components across the 5 segments. The total score ranges from 0 to 60. Higher scores mean a worse outcome
Maintenance Phase Efficacy - CDAI clinical remission	Week 52	Proportion of subjects with CDAI clinical remission at Week 52 Proportion of subjects with sustained CDAI clinical remission at Week 52
Induction and maintenance Phase Efficacy- Crohn's Disease Activity Index (CDAI)	Week 12 and week 52	Change from baseline in Crohn's Disease Activity Index (CDAI) score at Week 12 and Week 52 The CDAI total score ranges from 0 to over 600. Higher scores mean a worse outcome.
Maintenance Phase Efficacy - Endoscopic response	Week 52	Proportion of subjects with endoscopic response at Week 52
Maintenance Phase Efficacy - PRO-2 clinical response	Week 52	Proportion of subjects with PRO-2 clinical response (≥ 30% decrease in average daily PRO-2 score (AP + SF) and both no higher than baseline) at Week 52
Maintenance Phase Efficacy - PRO-2 clinical remission	Week 52	Proportion of subjects with patient reported outcome (PRO)-2 clinical remission at Week 52
Maintenance Phase Efficacy - SES-CD ulcer subscore > 1	Week 52	Proportion of subjects with no SES-CD ulcer subscore \> 1 in at least one segment at Week 52
Maintenance Phase Efficacy - CDAI clinical response	Week 52	Proportion of subjects with CDAI clinical response (CDAI decrease from baseline ≥ 100 points) at Week 52
Extension Phase Safety - Hematology and coagulation	Weeks 64, 76, 88,100 and EOS	Number of patients with clinically-significant abnormal laboratory parameters. Hematology: Hematocrit, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular volume, platelet count, red blood cells; white blood cells Coagulation: International normalized ratio, activated partial thromboplastin time, fibrinogen, prothrombin time
Maintenance Phase Efficacy - CDAI clinical response and endoscopic response	Week 52	Proportion of subjects with CDAI clinical response and endoscopic response at Week 52
Maintenance Phase Efficacy - endoscopic remission	Week 52	Proportion of subjects with endoscopic remission at Week 52
Extension Phase Safety- Adverse events	Weeks 64, 76, 88,100 and EOS	Incidence of all treatment-emergent adverse events (TEAEs), serious adverse events (SAEs) and causally related TEAEs/SAEs Incidence of adverse events (AEs) leading to discontinuation
Extension Phase Safety - Biochemistry	Weeks 64, 76, 88,100 and EOS	Number of patients with clinically-significant abnormal laboratory parameters. Albumin, total protein, aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH), lipase, amylase, creatinine, creatinine clearance, urea, chloride, bicarbonate, sodium, potassium, calcium, phosphate, uric acid, glucose, total cholesterol, LDL cholesterol (direct), HDL cholesterol, triglycerides, creatine phosphokinase (CPK), high sensitivity troponin I and T, N-terminal prohormone of brain natriuretic peptide (NT-proBNP)

Secondary Outcome Measures

Name	Time	Method
Induction Phase Efficacy - endoscopic remission	Week 12	Proportion of subjects with endoscopic remission at Week 12
Induction Phase Efficacy - SES-CD	Week 12	Change from baseline in Simple Endoscopic Score for Crohn's disease (SES-CD) at Week 12
Induction Phase Efficacy - Endoscopic response	Week 12	Proportion of subjects with endoscopic response at Week 12
Induction Phase Efficacy-SES-CD ulcer subscore > 1	Week 12	Proportion of subjects with no SES-CD ulcer subscore \> 1 in at least one segment at Week 12
Induction Phase Efficacy-CDAI clinical remission	Week 12	Proportion of subjects with Crohn's Disease Activity Index (CDAI) clinical remission (CDAI score \< 150) at Week 12 The total CDAI score ranges from 0 to over 600. Higher scores mean a worse outcome
Induction Phase Efficacy-PRO-2 clinical remission	Week 12	Proportion of subjects with patient reported outcome (PRO)-2 clinical remission (Combination of average daily abdominal pain score ≤ 1.0 plus average daily soft or liquid stool frequency ≤ 2.8 and both no higher than baseline) at Week 12
Induction Phase Efficacy-CDAI clinical response	Week 12	Proportion of subjects with CDAI clinical response (CDAI decrease from baseline ≥ 100 points) at Week 12 The total CDAI score ranges from 0 to over 600. Higher scores mean a worse outcome
Induction Phase Efficacy-PRO-2 clinical response	Week 12	Proportion of subjects with PRO-2 clinical response at Week 12
Induction Phase Efficacy-CDAI clinical response and endoscopic response	Week 12	Proportion of subjects with CDAI clinical response (CDAI decrease from baseline ≥ 100 points) and endoscopic response (Simple Endoscopic Score for Crohn's disease (SES-CD) decrease from baseline ≥ 50%) at Week 12; The total CDAI score ranges from 0 to over 600. Higher scores mean a worse outcome The total SES-CD score ranges from 0 to 60. Higher scores mean a worse outcome.

Trial Locations

Locations (148)

Centrum Medyczne Plejady; 🇵🇱 Kraków, Poland

IMC Gulf Coast Gastroenterology, PC; 🇺🇸 Fairhope, Alabama, United States

Scottsdale Gastroenterology Specialists; 🇺🇸 Scottsdale, Arizona, United States

GI Alliance -Gurnee; 🇺🇸 Sun City, Arizona, United States

Hoag Hospital; 🇺🇸 Irvine, California, United States

United Medical Doctors; 🇺🇸 Murrieta, California, United States

Peak Gastroenterology Associates; 🇺🇸 Colorado Springs, Colorado, United States

Clinical Research Of Brandon, LLC; 🇺🇸 Brandon, Florida, United States

West Central Gastroenterology d/b/a Gastro Florida; 🇺🇸 Clearwater, Florida, United States

Auzmer Research; 🇺🇸 Lakeland, Florida, United States

Wellness Clinical Research; 🇺🇸 Miami Lakes, Florida, United States

Research Associates of South Florida, LLC; 🇺🇸 Miami, Florida, United States

Advanced Research Institute, Inc.; 🇺🇸 New Port Richey, Florida, United States

Sarkis Clinical Trials - Parent; 🇺🇸 Ocala, Florida, United States

Orlando Health, Inc.; 🇺🇸 Orlando, Florida, United States

GCP Clinical Research, LLC; 🇺🇸 Tampa, Florida, United States

Theia Clinical Research Centers, LLC; 🇺🇸 Temple Terrace, Florida, United States

Northwestern University; 🇺🇸 Evanston, Illinois, United States

University of Iowa Health Care; 🇺🇸 Iowa City, Iowa, United States

Lucida Clinical Trials, LLC; 🇺🇸 New Bedford, Massachusetts, United States

University of Massachusetts, Worcester; 🇺🇸 Worcester, Massachusetts, United States

Henry Ford Columbus Center; 🇺🇸 Detroit, Michigan, United States

Dartmouth-Hitchcock Medical Center; 🇺🇸 Lebanon, New Hampshire, United States

OSU Inflammatory Bowel Disease Center; 🇺🇸 Hilliard, Ohio, United States

Susquehanna Research Group, LLC; 🇺🇸 Harrisburg, Pennsylvania, United States

UPMC; 🇺🇸 Pittsburgh, Pennsylvania, United States

Frontier Clinical Research, LLC; 🇺🇸 Uniontown, Pennsylvania, United States

Rapid City Medical Center, LLC; 🇺🇸 Rapid City, South Dakota, United States

Vanderbilt University Medical Center; 🇺🇸 Nashville, Tennessee, United States

Central Texas Clinical Research, LLC; 🇺🇸 Austin, Texas, United States

Inquest Clinical Research; 🇺🇸 Baytown, Texas, United States

Novel Research, LLC; 🇺🇸 Bellaire, Texas, United States

GI Alliance; 🇺🇸 Cedar Park, Texas, United States

Baylor University Hospital; 🇺🇸 Dallas, Texas, United States

GI Alliance - Garland; 🇺🇸 Garland, Texas, United States

Texas Digestive Specialists; 🇺🇸 Harlingen, Texas, United States

Houston Methodist Hospital; 🇺🇸 Houston, Texas, United States

GI Alliance - Gurnee; 🇺🇸 Mansfield, Texas, United States

Southern Star Research Institute, LLC; 🇺🇸 San Antonio, Texas, United States

Tyler Research Institute, LLC; 🇺🇸 Tyler, Texas, United States

University of Utah; 🇺🇸 Salt Lake City, Utah, United States

Richmond VA Medical Center; 🇺🇸 Richmond, Virginia, United States

Valahia Medical SRL; 🇷🇴 Ploieşti, Romania

Gastroenterology Consultants of Southwest Virginia.; 🇺🇸 Roanoke, Virginia, United States

University of Washington; 🇺🇸 Seattle, Washington, United States

Hopital Universitaire de Bruxelles - Hopital Erasme; 🇧🇪 Bruxelles, Belgium

AZ Maria Middelares; 🇧🇪 Gent, Belgium

Universitair Ziekenhuis Gent; 🇧🇪 Gent, Belgium

UZ Leuven; 🇧🇪 Leuven, Belgium

Centre Wallonie Picarde; 🇧🇪 Tournai, Belgium

CHU UCL Namur; 🇧🇪 Yvoir, Belgium

SurGal Clinic s.r.o.; 🇨🇿 Brno, Czechia

Vojenska nemocnice Brno; 🇨🇿 Brno, Czechia

Hepato-Gastroenterologie HK s.r.o.; 🇨🇿 Hradec Králové, Czechia

PreventaMed s.r.o.; 🇨🇿 Olomouc, Czechia

ISCARE a.s.; 🇨🇿 Praha, Czechia

Nemocnice Slany; 🇨🇿 Slaný, Czechia

CHU Amiens; 🇫🇷 Amiens, France

CHU Besançon - Hôpital Jean Minjoz; 🇫🇷 Besançon, France

CHU Clermont Ferrand - Hopital d'Estaing; 🇫🇷 Clermont-Ferrand, France

Hôpital Henri Mondor; 🇫🇷 Créteil, France

CHU Dijon - Hôpital Bocage Central; 🇫🇷 Dijon, France

CHU de Grenoble - Hôpital Michallon; 🇫🇷 Grenoble, France

Centre Hospitalier Départemental Vendée - Les Oudairies; 🇫🇷 La Roche-sur-Yon, France

Hôpital Bicêtre; 🇫🇷 Le Kremlin-Bicêtre, France

CHU Lille - Hôpital Claude Huriez; 🇫🇷 Lille, France

Hôpital Nord - CHU Marseille; 🇫🇷 Marseille, France

Hopital Saint Eloi; 🇫🇷 Montpellier, France

CHU Nantes - Hôtel Dieu; 🇫🇷 Nantes, France

Institut des MICI; 🇫🇷 Neuilly-sur-Seine, France

CHU Nice - Hôpital de l'Archet 2; 🇫🇷 Nice, France

CHU Bordeaux - Hôpital Haut-Lévêque; 🇫🇷 Pessac, France

Centre Hospitalier Lyon Sud; 🇫🇷 Pierre-Bénite, France

CHU Saint Etienne - Hôpital Nord; 🇫🇷 Saint-Étienne, France

Hopital Rangueil; 🇫🇷 Toulouse, France

Hôpital de Brabois; 🇫🇷 Vandœuvre-lès-Nancy, France

Charite-Campus Benjamin Franklin Medizin.Klin.I; 🇩🇪 Berlin, Germany

Krankenhaus Waldfriede e. V.; 🇩🇪 Berlin, Germany

Universitaetsklinikum Brandenburg an der Havel; 🇩🇪 Brandenburg an der Havel, Germany

Universitaetsklinikum Erlangen; 🇩🇪 Erlangen, Germany

Universitaetsklinikum Frankfurt Goethe-Universitaet; 🇩🇪 Frankfurt am Main, Germany

Hamburgisches Forschungsinstitut fuer Chronisch Entzuendliche Darmerkrankungen; 🇩🇪 Hamburg, Germany

Medizinische Hochschule Hannover; 🇩🇪 Hannover, Germany

Universitaetsklinikum Heidelberg; 🇩🇪 Heidelberg, Germany

Universitaetsklinikum Schleswig-Holstein - Campus Kiel; 🇩🇪 Kiel, Germany

St. Marienkrankenhaus; 🇩🇪 Ludwigshafen, Germany

LMU - Campus Grosshadern; 🇩🇪 Muenchen, Germany

Universitaetsklinikum Ulm; 🇩🇪 Ulm, Germany

Obudai Egeszsegugyi Centrum Kft.; 🇭🇺 Budapest, Hungary

Pannonia Maganorvosi Centrum; 🇭🇺 Budapest, Hungary

Semmelweis Egyetem; 🇭🇺 Budapest, Hungary

Bekes Varmegyei Kozponti Korhaz; 🇭🇺 Békéscsaba, Hungary

Gyongyosi Bugat Pal Korhaz; 🇭🇺 Gyöngyös, Hungary

Clinfan Szolgaltato Kft.; 🇭🇺 Szekszárd, Hungary

Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz; 🇭🇺 Székesfehérvár, Hungary

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS; 🇮🇹 Bologna, Italy

Azienda Ospedaliera Universitaria Renato Dulbecco di Catanzaro; 🇮🇹 Catanzaro, Italy

Ospedale San Raffaele; 🇮🇹 Milano, Italy

Ospedale Sacro Cuore Don Calabria; 🇮🇹 Negrar, Italy

Fondazione IRCCS Policlinico San Matteo; 🇮🇹 Pavia, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS; 🇮🇹 Roma, Italy

Università Campus Bio-Medico di Roma; 🇮🇹 Roma, Italy

Istituto Clinico Humanitas; 🇮🇹 Rozzano, Italy

IRCCS Ospedale Casa Sollievo della Sofferenza; 🇮🇹 San Giovanni Rotondo, Italy

Amsterdam UMC, Locatie AMC; 🇳🇱 Amsterdam, Netherlands

Maastricht University Medical Center; 🇳🇱 Maastricht, Netherlands

Radboud UMC; 🇳🇱 Nijmegen, Netherlands

ETZ Elisabeth; 🇳🇱 Tilburg, Netherlands

Bernhoven Uden; 🇳🇱 Uden, Netherlands

Centrum Medyczne Medis; 🇵🇱 Bydgoszcz, Poland

NZOZ Centrum Medyczne KERmed; 🇵🇱 Bydgoszcz, Poland

Polimedica Centrum Badań, Profilaktyki I Leczenia; 🇵🇱 Kielce, Poland

Mz Badania Slowik Zymla Sp J; 🇵🇱 Knurów, Poland

Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej; 🇵🇱 Leczna, Poland

ALLMEDICA sp. z o. o.; 🇵🇱 Nowy Targ, Poland

Twoja Przychodnia Opolskie Centrum Medyczne; 🇵🇱 Opole, Poland

Trialmed CRS; 🇵🇱 Piotrków Trybunalski, Poland

SOLUMED Centrum Medyczne; 🇵🇱 Poznan, Poland

NSZOZ Termedica - Centrum Badan Klinicznych; 🇵🇱 Poznań, Poland

Twoja Przychodnia PCM; 🇵🇱 Późna, Poland

Gabinet Lekarski Bartosz Korczowski; 🇵🇱 Rzeszów, Poland

Kiepury Clinic MAŁGORZATA JARNOT SPECJALISTYCZNA PRAKTYKA GINEKOLOGICZNO-POŁOŻNICZA; 🇵🇱 Sosnowiec, Poland

Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o.; 🇵🇱 Szczecin, Poland

Centrum Zdrowia MDM; 🇵🇱 Warszawa, Poland

Medical Network Spolka z o.o; 🇵🇱 Warszawa, Poland

NZOZ VIVAMED Jadwiga Miecz; 🇵🇱 Warszawa, Poland

Melita Medical Sp. Z O. O.; 🇵🇱 Wrocław, Poland

ETG Zamosc; 🇵🇱 Zamość, Poland

AMICARE spółka z ograniczoną odpowiedzialnością spółka komandytowa; 🇵🇱 Łódź, Poland

DC-MED; 🇵🇱 Świdnica, Poland

S.C Delta Health Care S.R.L; 🇷🇴 Bucuresti, Romania

SC Centrul Medical Medicum SRL, Specialitatea Gastroenterologie; 🇷🇴 Bucuresti, Romania

Spitalul Clinic Colentina; 🇷🇴 Bucuresti, Romania

S.C Pelican Impex S.R.L; 🇷🇴 Oradea, Romania

Fakultna nemocnica s poliklinikou F.D. Roosevelta; 🇸🇰 Banská Bystrica, Slovakia

Cliniq s.r.o.; 🇸🇰 Bratislava, Slovakia

Endomed, s.r.o.; 🇸🇰 Košice, Slovakia

KM Management spol. s r.o.; 🇸🇰 Nitra, Slovakia

Gastro I, s.r.o.; 🇸🇰 Prešov, Slovakia

Svet zdravia a.s.; 🇸🇰 Rimavská Sobota, Slovakia

Centro Medico Teknon; 🇪🇸 Barcelona, Spain

Hospital Universitario Reina Sofia; 🇪🇸 Córdoba, Spain

Hospital Universitario de Fuenlabrada; 🇪🇸 Fuenlabrada, Spain

Hospital General Juan Ramon Jimenez; 🇪🇸 Huelva, Spain

Hospital Universitario de Gran Canaria Dr. Negrin; 🇪🇸 Las Palmas De Gran Canaria, Spain

Clinica Gaias - Santiago; 🇪🇸 Santiago De Compostela, Spain

Hospital Universitario Virgen del Rocio; 🇪🇸 Sevilla, Spain

Hospital Clinico Universitario de Valencia; 🇪🇸 Valencia, Spain