CT Coronary Angiography: Coronary Flow Quantification Supplements Morphological Stenosis Analysis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- University of Cologne
- Enrollment
- 50
- Status
- Completed
- Last Updated
- 16 years ago
Overview
Brief Summary
The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying the significance and hemodynamic relevance of a stenosis and thereby supplement as a functional parameter for morphological stenosis analysis.
Detailed Description
A total of 50 patients prospectively underwent computed tomography coronary angiography (CTCA) in a multidetector CT scanner (Brilliance 64, Philips) ± 1 day before or after invasive coronary angiography (ICA). Immediately thereafter, 2 radiologists reviewed the imaging data to detect any vessel segments with morphology poorly evaluable by CTCA. A locally constant cyclical measurement was acquired in these coronary arteries in breath-hold technique during the passage of a 50ml bolus of contrast media. For analysis, time-density curves of the bolus passage were registered in the coronary artery and the aorta (internal reference), the up-slopes were determined and correlated with each other. The results were compared with the ICA findings.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinically known or presumed CAD
- •Age \> 50 years
- •Hospitalization for invasive coronary angiography
- •Sinus rhythm
- •Written informed consent by the patient to participate in the study after comprehensive presentation of the facts
Exclusion Criteria
- •Age \<= 50 years
- •Contraindications to contrast media administration (medical history of iodine allergy, nephropathy, latent or manifest hyperthyroidism)
- •Arrhythmias
- •Dyspnea at rest, acute unstable angina pectoris, acute myocardial infarction
- •Pregnancy
- •Implanted pacemaker
- •Unwillingness of patient to consent to the study
Outcomes
Primary Outcomes
Not specified