China Atrial Fibrillation With Complex Metabolic Disorders Cohort Study (CAME Cohort)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 3,459
- 主要终点
- Major Adverse Cardiovascular Events (MACE)
研究概览
简要总结
The number of atrial fibrillation (AF) patients in China is approximately 32.76 million, with a prevalence rate of 2.3%. AF is associated with severe outcomes such as stroke and heart failure. Metabolic disorders (e.g., obesity, diabetes mellitus, dyslipidemia) are closely linked to the onset and prognosis of AF. However, the epidemiological characteristics and disease burden of AF combined with metabolic disorders in China remain unclear. Additionally, the impact of complex multi-dimensional metabolic disorders on AF prognosis requires further investigation, and current clinical guidelines lack targeted management recommendations for this population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Major Adverse Cardiovascular Events (MACE)
时间窗: From enrollment to the end of follow-up at 5 years
Major Adverse Cardiovascular Events (MACE) - Composite outcome including the following components, all assessed during the entire follow-up period: * All-cause mortality: Defined as any death regardless of cause, confirmed by death certificate, medical records or family report. * Stroke: Defined as acute focal neurological deficit lasting ≥24 hours (or leading to death within 24 hours) due to cerebral infarction or intracerebral hemorrhage, confirmed by cranial computed tomography (CT) or magnetic resonance imaging (MRI). * Heart failure-related hospitalization: Defined as hospitalization requiring inpatient treatment due to worsening heart failure symptoms (e.g., dyspnea, edema), with objective evidence of heart failure exacerbation (e.g., elevated BNP, pulmonary congestion on chest imaging).
次要结局
- Cardiovascular mortality(From enrollment to the end of follow-up at 5 years)
- Cognitive impairment assessed by the Mini-Mental State Examination (MMSE) scale(From enrollment to the end of follow-up at 5 years)
- Quality of life: Assessed by the Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire(From enrollment to the end of follow-up at 5 years)
- Atrial fibrillation (AF) treated with catheter ablation for 2 or more times(From enrollment to the end of follow-up at 5 years)