Effectiveness of Dexmedetomidine vs Lignocaine 4% nebulization to attenuate haemodynamic response during laryngoscopy
试验速览
- 阶段
- 1/2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- To evaluate the Effectiveness of Dexmedetomidine and Lignocaine 4% nebulization in attenuating hemodynamic response during laryngoscopy. Laryngoscopy and Intubation responses result in increased circulatory catecholamines, heart rate (HR), blood pressure, myocardial oxygen demand, and dysrhythmias. The rise in HR and blood pressure is usually transient, variable, and unpredictable.
研究概览
简要总结
After obtaining the approval from Institutional Ethics Committee and written informed consent; a prospective, randomized, double blind, controlled study will be recruiting 120 adult patients posted for elective surgery under GA. The cases will be randomly allocated with sealed envelope with computer generated numbers in two groups, in which traditional protocol will be kept as control.
They will be randomized into two groups: Group D and Group L.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA Grade 1 and 2.
排除标准
- •Emergency operations Uncontrolled systemic disease Obese individuals Anticipated difficult intubation.
结局指标
主要结局
To evaluate the Effectiveness of Dexmedetomidine and Lignocaine 4% nebulization in attenuating hemodynamic response during laryngoscopy. Laryngoscopy and Intubation responses result in increased circulatory catecholamines, heart rate (HR), blood pressure, myocardial oxygen demand, and dysrhythmias. The rise in HR and blood pressure is usually transient, variable, and unpredictable.
时间窗: To evaluate hemodynamic status (Pulse rate, blood pressure, MBP, Spo2), Ramsay sedation score in time points of 2 mins, 5 mins, 10 mins, 15 mins and 20 mins after intubation
次要结局
- 1. To compare intra-operative hemodynamic parameters (HR, SBP, DBP, MAP) in both groups.(2. To determine the level of sedation)
研究者
Dr Farhan Moosani
Pandit Deendayal Upadhyay Medical College