Study of Efficacy of Induction Chemotherapy With Gemcitabine and Carboplatin for Operable Non-small-cell Lung Cancer Before Surgery

Phase 2

• Conditions: Lung Neoplasms

• Registration Number: NCT00563160
• Lead Sponsor: Hospital Authority, Hong Kong

Brief Summary

To study the activity of chemotherapy with Gemzar-carboplatin in the preoperative setting for operable stages of non-small-cell lung cancer and to identify novel molecular markers correlated with chemosensitivity and prognosis

Detailed Description

Not available

Study Timeline

• Study Start: 2005-05
• Study Completion: 2007-02
• Study First Submitted: 2007-11-21
• Study First Submitted QC: 2007-11-23
• Study First Posted: 2007-11-26
• Status Verified: 2010-07
• Last Update Submitted: 2010-07-06
• Last Update Posted: 2010-07-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Histologically or cytologically proven, newly diagnosed primary bronchogenic non-small cell lung cancer
• Measurable or evaluable tumour on chest X-ray or CT scan.
• No multiple ipsilateral or contralateral parenchymal tumours
• Stage I(exceptT1N0),II,IIIa disease as shown by PET-CT

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
pathological response rate	12 months

Secondary Outcome Measures

Name	Time	Method
progression-free survival	18 months
overall survival	18 months
quality of life measurements	18 months

Trial Locations

Locations (1)

Queen Elizabeth Hospital; 🇨🇳 Hong Kong, China