The Impact of the Previous Exposure to Covid-19 Virus Infection on the Outcome of ICSI Cycles

Completed

• Conditions: COVID-19; IVF
• Interventions: Other: covid-19

• Registration Number: NCT05198401
• Lead Sponsor: Al Baraka Fertility Hospital

Brief Summary

Whilst the global COVID-19 pandemic is still evolving and there are many unknowns about the long-term effects of the virus on fertility and pregnancy, we found ourselves in need to offer some evidence-based guidance, that's why we decided to go for this study, to evaluate the relation of the covid-19 and the outcome of IVF/ICSI cycles. we found that there is no clear evidence that the previous exposure to Covid-19 virus infection can affect the outcome of ICSI cycles significantly.

Detailed Description

This is an observational study, for 122 ICSI cycles conducted in Al- Baraka Fertility Hospital, Manama, Bahrain, and Al-Manea hospital, KSA between August 2020 and May 2021, and it was approved by the ethical committees. We compared the outcome results of those patients who got recovered from previous exposure to covid-19 (study group) with results of non-infected comparable patients (control group) After comparison of the basal characteristics in both groups, and we got assured that there is no significant difference regarding the demographic criteria between both groups, we found that there is no significant difference regarding the duration of stimulation, the total dose of stimulation, number of oocytes retrieved, number of metaphase 2 oocytes (MII), number of grade1-2 embryos, number of transferred embryos, day of embryo transfer and fertilization rate.

Although the fertilization rate was higher in Covid-19 free patients (52% vs. 50.6%), however, this difference is not statistically significant.

In the same way, the pregnancy rate was also higher in the covid-19 negative group (45.1% vs. 36.4%); however this difference was not statistically significant.

Study Timeline

• Study Start: 2020-08-01
• Primary Completion: 2021-05-02
• Study Completion: 2021-05-02
• Status Verified: 2022-01
• Study First Submitted: 2022-01-15
• Study First Submitted QC: 2022-01-19
• Last Update Submitted: 2022-01-19
• Study First Posted: 2022-01-20
• Last Update Posted: 2022-01-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 122

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	covid-19	(previous covid-19 positive) n. =88

Primary Outcome Measures

Name	Time	Method
number of mature oocytes (MII)	10 days	how many mature oocytes

Secondary Outcome Measures

Name	Time	Method
B-hcg	4 weeks	the clinical pregnancy rate.
total number of blastocysts	15 days	number of blastocysts

Trial Locations

Locations (1)

Kamal Eldin Abdalla Rageh; 🇪🇬 Cairo, Egypt