Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial
Recruiting
- Conditions
- COPDMechanical VentilationWeaning From Mechanical Ventilation
- Interventions
- Registration Number
- NCT07022704
- Lead Sponsor
- Cairo University
- Brief Summary
Researchers aim to evaluate the impact of doxapram administration on diaphragmatic excursion in chronic obstructive pulmonary disease (COPD) patients undergoing spontaneous breathing trial
- Detailed Description
doxapram will be administered intravenously (IV) during spontaneous breathing trial. diaphragmatic excursion will be evaluated by an expert in respiratory muscle ultrasound
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
- Patients with moderate to severe chronic obstructive pulmonary disease undergoing spontaneous breathing trial
Exclusion Criteria
- Refusal Allergy to doxapram neuromuscular disorders inability to evaluate the diaphragm
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Doxapram Doxapram All patients will receive doxapram during spontaneous breathing trial
- Primary Outcome Measures
Name Time Method • Diaphragmatic excursion in mm before and 10 minutes after doxappram
- Secondary Outcome Measures
Name Time Method Respiratory rate before and 10 minutes after doxapram Arterial blood gases before and 10 minutes after doxapram
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does doxapram target to enhance diaphragmatic excursion in COPD patients on mechanical ventilation?
How does doxapram compare to standard-of-care bronchodilators in improving respiratory muscle function during weaning from mechanical ventilation in COPD patients?
Are there specific biomarkers that correlate with improved diaphragmatic excursion following doxapram administration in COPD patients undergoing spontaneous breathing trials?
What are the potential adverse events associated with intravenous doxapram use in mechanically ventilated COPD patients and how can they be managed?
What combination therapies or alternative drugs show promise in enhancing diaphragmatic function for COPD patients undergoing mechanical ventilation weaning processes?
Trial Locations
- Locations (1)
Cairo University
🇪🇬Cairo, Cairo Governorate, Egypt
Cairo University🇪🇬Cairo, Cairo Governorate, EgyptCairo UniversityContact01007174836kasralainirec@gmail.com