Association of Heart Rate With Cardiovascular Disease Prognosis of Patients With Stable Coronary Artery Disease: A CALIBER Study
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- University College, London
- Enrollment
- 51,703
- Locations
- 1
- Primary Endpoint
- Risk of cardiovascular diseases in patients with low and high heart rate and stable coronary artery disease
Study Overview
Brief Summary
The Cardiovascular disease research using Linked Bespoke studies and Electronic Records (CALIBER) e-health database was the data resource for this study. CALIBER links patient records from four different data sources: Clinical Practice Research Database (CPRD), MINAP (Myocardial Ischaemia National Audit Project registry) Hospital Episodes Statistics (HES), the Office for National Statistics (ONS).
Detailed Description
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Aged >=30 years at study entry ->=1 year registration prior to the 'index date'
Exclusion Criteria
- •Free from previous atherosclerotic events
- •No heart rate measurement after their 'index date' of eligibility to entry the study
Outcomes
Primary Outcomes
Risk of cardiovascular diseases in patients with low and high heart rate and stable coronary artery disease
Time Frame: expected average of 3 years
Participants were followed until their first cardiovascular or complication event after their studyentry and after at least one previous cardiovascular event. Hazard ratios will be presenting associations between heart rate (analysed as quintiles and as continuous per 10bpm) and 8 different cardiovascular diseases (including mortality outcomes, complications such as bleeding events and composite cerebrovascular and coronary heart disease endpoints).
Secondary Outcomes
No secondary outcomes reported
Investigators
Harry Hemingway
Professor
University College, London