Randomized study to compare the radiation exposure of the hematological system by different radiation concepts in radiotherapy of head and neck tumors with elective lymph node irradiatio

Not Applicable

Recruiting

• Conditions: C10; C11; C32; C13; C14; Malignant neoplasm of oropharynx; Malignant neoplasm of nasopharynx; Malignant neoplasm of larynx; Malignant neoplasm of hypopharynx; Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx

• Registration Number: DRKS00034748
• Lead Sponsor: niversitätsmedizin Mainz

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-26
• Last Update Posted: 2024-08-19

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Pathological evidence of laryngeal, hypopharyngeal, p16 negative oropharyngeal or oral cavity carcinoma
Indication for radiotherapy provided by the tumor board
Typical clinical symptoms and sufficient medical history
General condition permits repeated venous blood sampling
Written patient consent to participate in the study is available

Exclusion Criteria

Known genetic defects associated with a reduction in DNA repair capacity (e.g. Werner syndrome, Fanconi anemia, ataxia telangiectasia)
Lack of consent
Pregnancy, breastfeeding
Legal guardianship in health matters by third parties
Severe mental illness
Exposure to ionizing radiation at least 5 days before the start of Radiotherapy

Study & Design

• Study Type: interventional
• Study Design: Not specified