Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or Observation in Treating Patients With High-Risk Uterine Leiomyosarcoma Previously Removed by Surgery

Phase 3

Terminated

Conditions: Stage I Uterine Sarcoma AJCC v7
Uterine Corpus Leiomyosarcoma

Interventions: Other: Clinical Observation
Drug: Docetaxel
Drug: Doxorubicin Hydrochloride
Biological: Filgrastim
Drug: Gemcitabine Hydrochloride
Biological: Pegfilgrastim

Registration Number: NCT01533207

Lead Sponsor: Gynecologic Oncology Group

Brief Summary: This randomized phase III trial studies how well gemcitabine hydrochloride and docetaxel followed by doxorubicin hydrochloride work compared to observation in treating patients with high-risk uterine leiomyosarcoma previously removed by surgery. Drugs used in chemotherapy, such as gemcitabine hydrochloride, docetaxel, and doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether combination therapy after surgery is an effective treatment for uterine leiomyosarcoma.

Detailed Description: PRIMARY OBJECTIVES:

I. To determine whether overall survival of patients with uterus-limited high-grade leiomyosarcoma is superior among patients assigned to treatment with adjuvant gemcitabine hydrochloride (gemcitabine) plus docetaxel followed by doxorubicin hydrochloride compared to patients assigned to observation.

SECONDARY OBJECTIVES:

I. To determine whether treatment with adjuvant gemcitabine plus docetaxel followed by doxorubicin improves recurrence-free survival of patients with uterus-limited high-grade leiomyosarcoma compared to observation.

II. To explore the impact of potential predictors of recurrence or death such as patient age, institution reported tumor size, cervix involvement (yes or no), and mitotic rate.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

Arm I: Patients receive adjuvant gemcitabine hydrochloride IV over 70-90 minutes on days 1 and 8 and docetaxel IV over 30-60 minutes on day 8. Patients also receive filgrastim subcutaneously (SC) on days 9-15 or pegfilgrastim SC on day 9 or 10. Treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. Patients then undergo computed tomography (CT) and/or magnetic resonance imaging (MRI). Patients with no evidence of disease receive doxorubicin hydrochloride IV every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients also receive filgrastim SC on days 2-8 or pegfilgrastim SC on day 2 or 3.

Arm II: Patients undergo clinical observation.

After completion of study treatment, patients in both arms are followed up every 4 months for 3 years and then every 6 months for 2 years.

Recruitment & Eligibility

Status: TERMINATED

Sex: Female

Target Recruitment: 38

Inclusion Criteria

Patients with high-risk uterine leiomyosarcoma (LMS), Federation of Gynecology and Obstetrics (FIGO) stage I (confined to corpus +/- cervix); patients with known uterine serosa involvement are not eligible; patients should have had, at least, a complete hysterectomy (including removal of the cervix); bilateral salpingo-oophorectomy is not required
- Institutional pathology review calls the uterine leiomyosarcoma ?high grade?
- Additionally, if the pathology report indicates a mitotic rate, the mitotic rate should be greater than or equal to 5 mitoses/10 high-power field
- All patients must be no longer than 12 weeks (3 months) from surgical resection of cancer at the time of enrollment on study; if a patient requires a second operation to complete her surgery, i.e., trachelectomy to remove the cervix and/or bilateral salpingo-oophorectomy (BSO), the 12 weeks may be counted from the time of the second operation
- Patients who had a ?morcellation? hysterectomy procedure that involved morcellation within the peritoneal cavity are eligible IF a second operation is performed and biopsies from the second procedure show no evidence of leiomyosarcoma
All patients must have no evidence of persistent or metastatic disease as documented by a post-resection computed tomography (CT) of the chest/abdomen/pelvis or by CT chest + magnetic resonance imaging (MRI) abdomen/pelvis; the post-resection imaging studies should be performed within 4 weeks of registration on study
Absolute neutrophil count (ANC) greater than or equal to 1,500/mcL (ANC >= 1.5 x 10^9/liter [L])
Platelets greater than or equal to 100,000/mcL (platelets >= 100 x 10^9/L)
Hemoglobin greater than 8.0 g/dL (= 80 g/L or 4.9 mmol/L)
Creatinine less than or equal to 1.5 x institutional upper limit of normal (ULN)
Bilirubin* within normal range
Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST])* and serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT])* less than or equal to 2.5 times ULN
Alkaline phosphatase* less than or equal to 2.5 x ULN
* Patients with a history of Gilbert?s syndrome may be eligible provided total bilirubin is less than or equal to 1.5 x ULN and the AST, ALT, and alkaline phosphatase meet the criteria detailed
Neuropathy (sensory and motor) less than or equal to Common Terminology Criteria for Adverse Events (CTCAE) grade 1
Patients with Gynecologic Oncology Group (GOG) performance status of 0 or 1 OR Eastern Cooperative Oncology Group (ECOG) PS of 0 or 1 OR Karnofsky performance status (PS) >= 80%
Patients who have met the pre-entry requirements specified
Patients must have signed an approved informed consent
Patients participating through United States (U.S.) sites must sign an approved and authorization permitting release of personal health information
Patients should be free of active infection requiring antibiotics (with the exception of an uncomplicated urinary tract infection [UTI])

Exclusion Criteria

Patients who have had prior therapy with docetaxel, gemcitabine hydrochloride, or doxorubicin hydrochloride at any time in their history
Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer, are ineligible if there is any evidence of other malignancy being present within the last five years; patients are also ineligible if their previous cancer treatment contraindicates this protocol therapy
Patients with a history of severe hypersensitivity reaction to Taxotere (docetaxel) or other drugs formulated with polysorbate 80
Patients with GOG performance status of 2, 3 or 4; or ECOG performance status of 2, 3 or 4
Patients who are breast-feeding
Patients with a known history of congestive heart failure or cardiac ejection fraction < 50% (or less than institutional normal limits); echocardiogram (ECHO) or multigated acquisition scan (MUGA) is not required prior to enrollment; for patients assigned to the chemotherapy arm, an ECHO or MUGA should be done within 6 months of day 1 of gemcitabine-docetaxel treatment
- Patients who enroll on study and are randomized to Regimen I (chemotherapy ) and then are found on baseline ECHO or MUGA to have cardiac ejection fraction < 50% or below institutional normal will remain ON study; such patients will receive gemcitabine + docetaxel for 4 cycles but will NOT receive any doxorubicin treatment; they will continue treatment follow-up as outlined for all patients assigned to Regimen I
Patients with a history of prior whole pelvic radiation
Concurrent treatment with hormone replacement therapy is permitted at the discretion of the treating physician; patients who have been taking hormonal/hormone blocking agents for breast cancer or breast cancer prevention or other indication are eligible; use of anti-hormonal agents (tamoxifen, medroxyprogesterone, aromatase inhibitors) is permitted at the discretion of the treating physician; documentation of concurrent medications is required
Patients with recurrent uterine LMS
Patients who are known to be human immunodeficiency virus (HIV) positive are not eligible
Patients with gross residual or metastatic tumor findings following complete surgical treatment for uterine LMS

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Arm I (chemotherapy)	Filgrastim	Patients receive adjuvant gemcitabine hydrochloride IV over 70-90 minutes on days 1 and 8 and docetaxel IV over 30-60 minutes on day 8. Patients also receive filgrastim SC on days 9-15 or pegfilgrastim SC on day 9 or 10. Treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. Patients then undergo CT and/or MRI. Patients with no evidence of disease receive doxorubicin hydrochloride IV every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients also receive filgrastim SC on days 2-8 or pegfilgrastim SC on day 2 or 3.
Arm I (chemotherapy)	Gemcitabine Hydrochloride	Patients receive adjuvant gemcitabine hydrochloride IV over 70-90 minutes on days 1 and 8 and docetaxel IV over 30-60 minutes on day 8. Patients also receive filgrastim SC on days 9-15 or pegfilgrastim SC on day 9 or 10. Treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. Patients then undergo CT and/or MRI. Patients with no evidence of disease receive doxorubicin hydrochloride IV every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients also receive filgrastim SC on days 2-8 or pegfilgrastim SC on day 2 or 3.
Arm I (chemotherapy)	Pegfilgrastim	Patients receive adjuvant gemcitabine hydrochloride IV over 70-90 minutes on days 1 and 8 and docetaxel IV over 30-60 minutes on day 8. Patients also receive filgrastim SC on days 9-15 or pegfilgrastim SC on day 9 or 10. Treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. Patients then undergo CT and/or MRI. Patients with no evidence of disease receive doxorubicin hydrochloride IV every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients also receive filgrastim SC on days 2-8 or pegfilgrastim SC on day 2 or 3.
Arm II (no treatment)	Clinical Observation	Patients undergo clinical observation.
Arm I (chemotherapy)	Docetaxel	Patients receive adjuvant gemcitabine hydrochloride IV over 70-90 minutes on days 1 and 8 and docetaxel IV over 30-60 minutes on day 8. Patients also receive filgrastim SC on days 9-15 or pegfilgrastim SC on day 9 or 10. Treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. Patients then undergo CT and/or MRI. Patients with no evidence of disease receive doxorubicin hydrochloride IV every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients also receive filgrastim SC on days 2-8 or pegfilgrastim SC on day 2 or 3.
Arm I (chemotherapy)	Doxorubicin Hydrochloride	Patients receive adjuvant gemcitabine hydrochloride IV over 70-90 minutes on days 1 and 8 and docetaxel IV over 30-60 minutes on day 8. Patients also receive filgrastim SC on days 9-15 or pegfilgrastim SC on day 9 or 10. Treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. Patients then undergo CT and/or MRI. Patients with no evidence of disease receive doxorubicin hydrochloride IV every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients also receive filgrastim SC on days 2-8 or pegfilgrastim SC on day 2 or 3.

Primary Outcome Measures

Name	Time	Method
Number of Participants Who Experienced Death	Follow-up every 4 months for 3 years, then every 6 months for 2 years.	The duration of time from study entry to time of death or the date of last contact.

Secondary Outcome Measures

Name	Time	Method
Incidence of Grade 3 or Higher Adverse Events as Assessed by National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.0	Approximately 4 years
Number of Participants With Recurrence	Follow-up every 4 months for 3 years, then every 6 months for 2 years.	The duration of time from study entry to time of recurrence or death, whichever occurred first, or the date of last contact.

Trial Locations

Locations (621): Johns Hopkins University/Sidney Kimmel Cancer Center
🇺🇸
Baltimore, Maryland, United States
Piedmont Hospital
🇺🇸
Atlanta, Georgia, United States
Grant Medical Center
🇺🇸
Columbus, Ohio, United States
The Mark H Zangmeister Center
🇺🇸
Columbus, Ohio, United States
Mount Carmel Health Center West
🇺🇸
Columbus, Ohio, United States
UPMC-Presbyterian Hospital
🇺🇸
Pittsburgh, Pennsylvania, United States
UPMC-Saint Clair Hospital Cancer Center
🇺🇸
Pittsburgh, Pennsylvania, United States
UPMC-Saint Margaret
🇺🇸
Pittsburgh, Pennsylvania, United States
UPMC Jefferson Regional Radiation Oncology
🇺🇸
Pittsburgh, Pennsylvania, United States
University of Pittsburgh Cancer Institute (UPCI)
🇺🇸
Pittsburgh, Pennsylvania, United States
Mount Sinai Hospital Medical Center
🇺🇸
Chicago, Illinois, United States
Northwestern University
🇺🇸
Chicago, Illinois, United States
Rush University Medical Center
🇺🇸
Chicago, Illinois, United States
Virginia Mason Medical Center
🇺🇸
Seattle, Washington, United States
Swedish Medical Center-Ballard Campus
🇺🇸
Seattle, Washington, United States
Oncology Hematology Care Inc-Eden Park
🇺🇸
Cincinnati, Ohio, United States
Good Samaritan Hospital - Cincinnati
🇺🇸
Cincinnati, Ohio, United States
Oncology Hematology Care Inc-Kenwood
🇺🇸
Cincinnati, Ohio, United States
Women's Cancer Center of Nevada
🇺🇸
Las Vegas, Nevada, United States
University of Cincinnati/Barrett Cancer Center
🇺🇸
Cincinnati, Ohio, United States
TriHealth Cancer Institute-Anderson
🇺🇸
Cincinnati, Ohio, United States
TriHealth Cancer Institute-Westside
🇺🇸
Cincinnati, Ohio, United States
Kaiser Permanente San Leandro
🇺🇸
San Leandro, California, United States
Welch Cancer Center
🇺🇸
Sheridan, Wyoming, United States
Billings Clinic-Cody
🇺🇸
Cody, Wyoming, United States
Zuckerberg San Francisco General Hospital
🇺🇸
San Francisco, California, United States
California Pacific Medical Center-Pacific Campus
🇺🇸
San Francisco, California, United States
University of New Mexico Cancer Center
🇺🇸
Albuquerque, New Mexico, United States
Virtua Memorial
🇺🇸
Mount Holly, New Jersey, United States
Virtua Voorhees
🇺🇸
Voorhees, New Jersey, United States
New York-Presbyterian/Brooklyn Methodist Hospital
🇺🇸
Brooklyn, New York, United States
Randolph Hospital
🇺🇸
Asheboro, North Carolina, United States
Duke University Medical Center
🇺🇸
Durham, North Carolina, United States
Oncology Specialists of Charlotte
🇺🇸
Charlotte, North Carolina, United States
Atrium Health Cabarrus/LCI-Concord
🇺🇸
Concord, North Carolina, United States
Novant Health Cancer Specialists-Matthews
🇺🇸
Matthews, North Carolina, United States
AdventHealth Hendersonville
🇺🇸
Hendersonville, North Carolina, United States
Matthews Radiation Oncology Center
🇺🇸
Matthews, North Carolina, United States
Lake Norman Hematology Oncology Specialists-Huntersville
🇺🇸
Huntersville, North Carolina, United States
Mid Dakota Clinic
🇺🇸
Bismarck, North Dakota, United States
UHHS-Chagrin Highlands Medical Center
🇺🇸
Beachwood, Ohio, United States
Strecker Cancer Center-Belpre
🇺🇸
Belpre, Ohio, United States
Dayton Physicians LLC-Miami Valley South
🇺🇸
Centerville, Ohio, United States
Adena Regional Medical Center
🇺🇸
Chillicothe, Ohio, United States
Bethesda North Hospital
🇺🇸
Cincinnati, Ohio, United States
Oncology Hematology Care Inc-Blue Ash
🇺🇸
Cincinnati, Ohio, United States
Marietta Memorial Hospital
🇺🇸
Marietta, Ohio, United States
Delaware Radiation Oncology
🇺🇸
Delaware, Ohio, United States
Lima Memorial Hospital
🇺🇸
Lima, Ohio, United States
Wayne Hospital
🇺🇸
Greenville, Ohio, United States
Toledo Clinic Cancer Centers-Maumee
🇺🇸
Maumee, Ohio, United States
Case Western Reserve University
🇺🇸
Cleveland, Ohio, United States
Oncology Hematology Care Inc-Healthplex
🇺🇸
Fairfield, Ohio, United States
Miami Valley Hospital
🇺🇸
Dayton, Ohio, United States
Grandview Hospital
🇺🇸
Dayton, Ohio, United States
Good Samaritan Hospital - Dayton
🇺🇸
Dayton, Ohio, United States
Wayne State University/Karmanos Cancer Institute
🇺🇸
Detroit, Michigan, United States
Dayton NCI Community Oncology Research Program
🇺🇸
Dayton, Ohio, United States
UH Seidman Cancer Center at Lake Health Mentor Campus
🇺🇸
Mentor, Ohio, United States
Ephrata Community Hospital
🇺🇸
Ephrata, Pennsylvania, United States
Legacy Mount Hood Medical Center
🇺🇸
Gresham, Oregon, United States
Upper Valley Medical Center
🇺🇸
Troy, Ohio, United States
Kettering Medical Center
🇺🇸
Kettering, Ohio, United States
Paoli Memorial Hospital
🇺🇸
Paoli, Pennsylvania, United States
Dayton Physicians LLC-Wayne
🇺🇸
Greenville, Ohio, United States
Blanchard Valley Hospital
🇺🇸
Findlay, Ohio, United States
Fairfield Medical Center
🇺🇸
Lancaster, Ohio, United States
Orion Cancer Care
🇺🇸
Findlay, Ohio, United States
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
🇺🇸
Maumee, Ohio, United States
Lancaster Radiation Oncology
🇺🇸
Lancaster, Ohio, United States
Knox Community Hospital
🇺🇸
Mount Vernon, Ohio, United States
Toledo Clinic Cancer Centers-Toledo
🇺🇸
Toledo, Ohio, United States
Dayton Physicians LLC-Wilson
🇺🇸
Sidney, Ohio, United States
Springfield Regional Cancer Center
🇺🇸
Springfield, Ohio, United States
Mercy Hospital of Tiffin
🇺🇸
Tiffin, Ohio, United States
Saint Ann's Hospital
🇺🇸
Westerville, Ohio, United States
Fulton County Health Center
🇺🇸
Wauseon, Ohio, United States
Saint Charles Health System
🇺🇸
Bend, Oregon, United States
Dayton Physicians LLC-Upper Valley
🇺🇸
Troy, Ohio, United States
Springfield Regional Medical Center
🇺🇸
Springfield, Ohio, United States
University of Toledo
🇺🇸
Toledo, Ohio, United States
Clackamas Radiation Oncology Center
🇺🇸
Clackamas, Oregon, United States
University Hospitals Sharon Health Center
🇺🇸
Wadsworth, Ohio, United States
UHHS-Westlake Medical Center
🇺🇸
Westlake, Ohio, United States
Easton Hospital
🇺🇸
Easton, Pennsylvania, United States
Wright-Patterson Medical Center
🇺🇸
Wright-Patterson Air Force Base, Ohio, United States
University of Oklahoma Health Sciences Center
🇺🇸
Oklahoma City, Oklahoma, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
🇺🇸
Greensburg, Pennsylvania, United States
Fox Chase Cancer Center
🇺🇸
Philadelphia, Pennsylvania, United States
Providence Oncology and Hematology Care Southeast
🇺🇸
Clackamas, Oregon, United States
Temple University Hospital
🇺🇸
Philadelphia, Pennsylvania, United States
UPMC-Magee Womens Hospital
🇺🇸
Pittsburgh, Pennsylvania, United States
Providence Newberg Medical Center
🇺🇸
Newberg, Oregon, United States
Greenville Health System Cancer Institute-Easley
🇺🇸
Easley, South Carolina, United States
WellSpan Health-York Cancer Center
🇺🇸
York, Pennsylvania, United States
UPMC-Passavant Hospital
🇺🇸
Pittsburgh, Pennsylvania, United States
Greenville Memorial Hospital
🇺🇸
Greenville, South Carolina, United States
WellSpan Health-York Hospital
🇺🇸
York, Pennsylvania, United States
West Penn Hospital
🇺🇸
Pittsburgh, Pennsylvania, United States
Greenville Health System Cancer Institute-Butternut
🇺🇸
Greenville, South Carolina, United States
Women and Infants Hospital
🇺🇸
Providence, Rhode Island, United States
Saint Francis Hospital
🇺🇸
Federal Way, Washington, United States
Lankenau Medical Center
🇺🇸
Wynnewood, Pennsylvania, United States
Geisinger Medical Group
🇺🇸
State College, Pennsylvania, United States
Saint Francis Cancer Center
🇺🇸
Greenville, South Carolina, United States
Geisinger Wyoming Valley/Henry Cancer Center
🇺🇸
Wilkes-Barre, Pennsylvania, United States
Fredericksburg Oncology Inc
🇺🇸
Fredericksburg, Virginia, United States
Greenville Health System Cancer Institute-Seneca
🇺🇸
Seneca, South Carolina, United States
Greenville Health System Cancer Institute-Greer
🇺🇸
Greer, South Carolina, United States
UPMC Uniontown Hospital Radiation Oncology
🇺🇸
Uniontown, Pennsylvania, United States
Memorial Hospital
🇺🇸
Chattanooga, Tennessee, United States
Pulmonary Medicine Center of Chattanooga-Hixson
🇺🇸
Hixson, Tennessee, United States
Greenville Health System Cancer Institute-Faris
🇺🇸
Greenville, South Carolina, United States
Overlake Hospital Medical Center
🇺🇸
Bellevue, Washington, United States
Swedish Cancer Institute-Eastside Oncology Hematology
🇺🇸
Bellevue, Washington, United States
Greenville Health System Cancer Institute-Spartanburg
🇺🇸
Spartanburg, South Carolina, United States
Harrison HealthPartners Hematology and Oncology-Bremerton
🇺🇸
Bremerton, Washington, United States
Memorial GYN Plus
🇺🇸
Ooltewah, Tennessee, United States
Virginia Mason Bainbridge Island Medical Center
🇺🇸
Bainbridge Island, Washington, United States
University of Texas Medical Branch
🇺🇸
Galveston, Texas, United States
Highline Medical Center-Main Campus
🇺🇸
Burien, Washington, United States
Parkland Memorial Hospital
🇺🇸
Dallas, Texas, United States
Providence Regional Cancer System-Centralia
🇺🇸
Centralia, Washington, United States
Providence Regional Cancer System-Lacey
🇺🇸
Lacey, Washington, United States
UT Southwestern/Simmons Cancer Center-Dallas
🇺🇸
Dallas, Texas, United States
Cancer Care Center at Island Hospital
🇺🇸
Anacortes, Washington, United States
MultiCare Gig Harbor Medical Park
🇺🇸
Gig Harbor, Washington, United States
Swedish Cancer Institute-Issaquah
🇺🇸
Issaquah, Washington, United States
Saint Elizabeth Hospital
🇺🇸
Enumclaw, Washington, United States
Franciscan Research Center-Northwest Medical Plaza
🇺🇸
Tacoma, Washington, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo
🇺🇸
Poulsbo, Washington, United States
Providence Regional Cancer System-Yelm
🇺🇸
Yelm, Washington, United States
Evergreen Hematology and Oncology PS
🇺🇸
Spokane, Washington, United States
Minor and James Medical PLLC
🇺🇸
Seattle, Washington, United States
Rockwood North Cancer Treatment Center
🇺🇸
Spokane, Washington, United States
Peninsula Cancer Center
🇺🇸
Poulsbo, Washington, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
🇺🇸
Yakima, Washington, United States
Universitair Ziekenhuis Antwerpen
🇧🇪
Edegem, Belgium
Kaiser Permanente Washington
🇺🇸
Seattle, Washington, United States
MultiCare Good Samaritan Hospital
🇺🇸
Puyallup, Washington, United States
PeaceHealth Southwest Medical Center
🇺🇸
Vancouver, Washington, United States
Big Horn Basin Cancer Center
🇺🇸
Cody, Wyoming, United States
Legacy Salmon Creek Hospital
🇺🇸
Vancouver, Washington, United States
Cheyenne Regional Medical Center-West
🇺🇸
Cheyenne, Wyoming, United States
Northwest Medical Specialties PLLC
🇺🇸
Tacoma, Washington, United States
Weston Park Hospital
🇬🇧
Sheffield, England, United Kingdom
Addenbrookes Hospital-Medical School
🇬🇧
Cambridge, England, United Kingdom
Rocky Mountain Oncology
🇺🇸
Casper, Wyoming, United States
Institute of Cancer Research - Chelsea
🇬🇧
London, United Kingdom
Vince Lombardi Cancer Clinic - Oshkosh
🇺🇸
Oshkosh, Wisconsin, United States
Institut Bergonie Cancer Center
🇫🇷
Bordeaux, France
Hospital Clinico San Carlos
🇪🇸
Madrid, Spain
University College London Hospital
🇬🇧
London, England, United Kingdom
Tennessee Valley Gynecologic Oncology
🇺🇸
Huntsville, Alabama, United States
Anchorage Associates in Radiation Medicine
🇺🇸
Anchorage, Alaska, United States
Alaska Women's Cancer Care
🇺🇸
Anchorage, Alaska, United States
Sutter Auburn Faith Hospital
🇺🇸
Auburn, California, United States
Alaska Regional Hospital
🇺🇸
Anchorage, Alaska, United States
Kaiser Permanente-Deer Valley Medical Center
🇺🇸
Antioch, California, United States
Anchorage Oncology Centre
🇺🇸
Anchorage, Alaska, United States
Fairbanks Memorial Hospital
🇺🇸
Fairbanks, Alaska, United States
CHI Saint Vincent Cancer Center Hot Springs
🇺🇸
Hot Springs, Arkansas, United States
Alta Bates Summit Medical Center-Herrick Campus
🇺🇸
Berkeley, California, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
🇺🇸
Cameron Park, California, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
🇺🇸
Burbank, California, United States
Kaiser Permanente-Fremont
🇺🇸
Fremont, California, United States
Kaiser Permanente-Fresno
🇺🇸
Fresno, California, United States
Kaiser Permanente-Modesto
🇺🇸
Modesto, California, United States
Palo Alto Medical Foundation-Gynecologic Oncology
🇺🇸
Mountain View, California, United States
Palo Alto Medical Foundation-Camino Division
🇺🇸
Mountain View, California, United States
Kaiser Permanente-Oakland
🇺🇸
Oakland, California, United States
Kaiser Permanente Medical Center - Santa Clara
🇺🇸
Santa Clara, California, United States
Kaiser Permanente-Redwood City
🇺🇸
Redwood City, California, United States
Kaiser Permanente-Roseville
🇺🇸
Roseville, California, United States
Kaiser Permanente-Santa Teresa-San Jose
🇺🇸
San Jose, California, United States
Kaiser Permanente-Stockton
🇺🇸
Stockton, California, United States
Sutter Roseville Medical Center
🇺🇸
Roseville, California, United States
Kaiser Permanente-South San Francisco
🇺🇸
South San Francisco, California, United States
Palo Alto Medical Foundation-Sunnyvale
🇺🇸
Sunnyvale, California, United States
Sutter Cancer Centers Radiation Oncology Services-Vacaville
🇺🇸
Vacaville, California, United States
Rocky Mountain Cancer Centers-Greenwood Village
🇺🇸
Greenwood Village, Colorado, United States
Kaiser Permanente Medical Center-Vacaville
🇺🇸
Vacaville, California, United States
Kaiser Permanente-Vallejo
🇺🇸
Vallejo, California, United States
Kaiser Permanente-Walnut Creek
🇺🇸
Walnut Creek, California, United States
Sutter Solano Medical Center/Cancer Center
🇺🇸
Vallejo, California, United States
Boulder Community Hospital
🇺🇸
Boulder, Colorado, United States
Southwest Oncology PC
🇺🇸
Durango, Colorado, United States
Mercy Medical Center
🇺🇸
Durango, Colorado, United States
Rocky Mountain Cancer Centers-Lakewood
🇺🇸
Lakewood, Colorado, United States
Rocky Mountain Cancer Centers-Littleton
🇺🇸
Littleton, Colorado, United States
Florida Hospital Kissimmee
🇺🇸
Kissimmee, Florida, United States
Rocky Mountain Cancer Centers - Pueblo
🇺🇸
Pueblo, Colorado, United States
Illinois CancerCare-Carthage
🇺🇸
Carthage, Illinois, United States
Rocky Mountain Cancer Centers-Thornton
🇺🇸
Thornton, Colorado, United States
Saint Luke's Mountain States Tumor Institute - Fruitland
🇺🇸
Fruitland, Idaho, United States
Centralia Oncology Clinic
🇺🇸
Centralia, Illinois, United States
Florida Hospital Cancer Institute Winter Park
🇺🇸
Winter Park, Florida, United States
John H Stroger Jr Hospital of Cook County
🇺🇸
Chicago, Illinois, United States
Summit Cancer Care-Memorial
🇺🇸
Savannah, Georgia, United States
Christiana Care Health System-Christiana Hospital
🇺🇸
Newark, Delaware, United States
Saint Luke's Mountain States Tumor Institute
🇺🇸
Boise, Idaho, United States
Sibley Memorial Hospital
🇺🇸
Washington, District of Columbia, United States
Florida Hospital Cancer Institute Altamonte
🇺🇸
Altamonte Springs, Florida, United States
Nanticoke Memorial Hospital
🇺🇸
Seaford, Delaware, United States
Regional Hematology and Oncology PA
🇺🇸
Newark, Delaware, United States
Northside Hospital
🇺🇸
Atlanta, Georgia, United States
Hawaii Oncology Inc-Pali Momi
🇺🇸
'Aiea, Hawaii, United States
Pali Momi Medical Center
🇺🇸
'Aiea, Hawaii, United States
Saint Luke's Mountain States Tumor Institute - Meridian
🇺🇸
Meridian, Idaho, United States
Saint Joseph Medical Center
🇺🇸
Bloomington, Illinois, United States
Memorial Health University Medical Center
🇺🇸
Savannah, Georgia, United States
Kootenai Cancer Center
🇺🇸
Post Falls, Idaho, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
🇺🇸
Savannah, Georgia, United States
The Cancer Center of Hawaii-Pali Momi
🇺🇸
'Aiea, Hawaii, United States
Dekalb Medical Center
🇺🇸
Decatur, Georgia, United States
Low Country Cancer Care Associates PC
🇺🇸
Savannah, Georgia, United States
Illinois CancerCare-Ottawa Clinic
🇺🇸
Ottawa, Illinois, United States
Kootenai Cancer Clinic
🇺🇸
Sandpoint, Idaho, United States
Saint Luke's Mountain States Tumor Institute-Twin Falls
🇺🇸
Twin Falls, Idaho, United States
Rush - Copley Medical Center
🇺🇸
Aurora, Illinois, United States
Kootenai Medical Center
🇺🇸
Coeur d'Alene, Idaho, United States
Illinois CancerCare-Bloomington
🇺🇸
Bloomington, Illinois, United States
Saint Joseph Regional Medical Center
🇺🇸
Lewiston, Idaho, United States
Saint Luke's Mountain States Tumor Institute - Nampa
🇺🇸
Nampa, Idaho, United States
Cancer Care Specialists of Illinois - Decatur
🇺🇸
Decatur, Illinois, United States
Decatur Memorial Hospital
🇺🇸
Decatur, Illinois, United States
University of Chicago Comprehensive Cancer Center
🇺🇸
Chicago, Illinois, United States
Carle on Vermilion
🇺🇸
Danville, Illinois, United States
NorthShore University HealthSystem-Evanston Hospital
🇺🇸
Evanston, Illinois, United States
McFarland Clinic PC - Ames
🇺🇸
Ames, Iowa, United States
Mercy Cancer Center-West Lakes
🇺🇸
Clive, Iowa, United States
Sudarshan K Sharma MD Limited-Gynecologic Oncology
🇺🇸
Hinsdale, Illinois, United States
Franciscan Saint Anthony Health-Michigan City
🇺🇸
Michigan City, Indiana, United States
Saint Vincent Hospital and Health Care Center
🇺🇸
Indianapolis, Indiana, United States
Radiation Oncology of Northern Illinois
🇺🇸
Ottawa, Illinois, United States
Illinois CancerCare-Pekin
🇺🇸
Pekin, Illinois, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
🇺🇸
Pekin, Illinois, United States
UC Comprehensive Cancer Center at Silver Cross
🇺🇸
New Lenox, Illinois, United States
McFarland Clinic PC-Boone
🇺🇸
Boone, Iowa, United States
Memorial Hospital of South Bend
🇺🇸
South Bend, Indiana, United States
Illinois CancerCare-Macomb
🇺🇸
Macomb, Illinois, United States
Illinois CancerCare-Peoria
🇺🇸
Peoria, Illinois, United States
Memorial Regional Cancer Center Day Road
🇺🇸
Mishawaka, Indiana, United States
Woodland Cancer Care Center
🇺🇸
Michigan City, Indiana, United States
Greater Regional Medical Center
🇺🇸
Creston, Iowa, United States
Valley Radiation Oncology
🇺🇸
Peru, Illinois, United States
Cancer Center of Kansas - Chanute
🇺🇸
Chanute, Kansas, United States
McFarland Clinic PC-Trinity Cancer Center
🇺🇸
Fort Dodge, Iowa, United States
Central Illinois Hematology Oncology Center
🇺🇸
Springfield, Illinois, United States
The Carle Foundation Hospital
🇺🇸
Urbana, Illinois, United States
Southern Illinois University School of Medicine
🇺🇸
Springfield, Illinois, United States
Reid Health
🇺🇸
Richmond, Indiana, United States
Springfield Clinic
🇺🇸
Springfield, Illinois, United States
Alegent Health Mercy Hospital
🇺🇸
Council Bluffs, Iowa, United States
Cancer Care Specialists of Illinois-Swansea
🇺🇸
Swansea, Illinois, United States
McFarland Clinic PC-Marshalltown
🇺🇸
Marshalltown, Iowa, United States
Cancer Center of Kansas-Kingman
🇺🇸
Kingman, Kansas, United States
Cancer Center of Kansas - McPherson
🇺🇸
McPherson, Kansas, United States
Minimally Invasive Surgery Hospital
🇺🇸
Lenexa, Kansas, United States
Cancer Center of Kansas-Liberal
🇺🇸
Liberal, Kansas, United States
Cancer Center of Kansas-Manhattan
🇺🇸
Manhattan, Kansas, United States
Cancer Center of Kansas - Parsons
🇺🇸
Parsons, Kansas, United States
University of Maryland/Greenebaum Cancer Center
🇺🇸
Baltimore, Maryland, United States
Bixby Medical Center
🇺🇸
Adrian, Michigan, United States
Mercy Hospital Joplin
🇺🇸
Joplin, Missouri, United States
Washington University School of Medicine
🇺🇸
Saint Louis, Missouri, United States
Mercy Hospital Saint Louis
🇺🇸
Saint Louis, Missouri, United States
Community Hospital of Anaconda
🇺🇸
Anaconda, Montana, United States
Great Falls Clinic
🇺🇸
Great Falls, Montana, United States
CHI Health Saint Francis
🇺🇸
Grand Island, Nebraska, United States
Saint Elizabeth Regional Medical Center
🇺🇸
Lincoln, Nebraska, United States
Montana Cancer Specialists
🇺🇸
Missoula, Montana, United States
Porter Adventist Hospital
🇺🇸
Denver, Colorado, United States
Colorado Blood Cancer Institute
🇺🇸
Denver, Colorado, United States
Presbyterian - Saint Lukes Medical Center - Health One
🇺🇸
Denver, Colorado, United States
Colorado Cancer Research Program NCORP
🇺🇸
Denver, Colorado, United States
Rocky Mountain Cancer Centers-Midtown
🇺🇸
Denver, Colorado, United States
SCL Health Saint Joseph Hospital
🇺🇸
Denver, Colorado, United States
Rose Medical Center
🇺🇸
Denver, Colorado, United States
Legacy Good Samaritan Hospital and Medical Center
🇺🇸
Portland, Oregon, United States
Providence Portland Medical Center
🇺🇸
Portland, Oregon, United States
Providence Saint Vincent Medical Center
🇺🇸
Portland, Oregon, United States
Centre Georges-Francois Leclerc
🇫🇷
Dijon, France
Nebraska Methodist Hospital
🇺🇸
Omaha, Nebraska, United States
Alegent Health Immanuel Medical Center
🇺🇸
Omaha, Nebraska, United States
Hematology and Oncology Consultants PC
🇺🇸
Omaha, Nebraska, United States
Alegent Health Bergan Mercy Medical Center
🇺🇸
Omaha, Nebraska, United States
Alegent Health Lakeside Hospital
🇺🇸
Omaha, Nebraska, United States
Creighton University Medical Center
🇺🇸
Omaha, Nebraska, United States
University of Nebraska Medical Center
🇺🇸
Omaha, Nebraska, United States
Aurora Saint Luke's Medical Center
🇺🇸
Milwaukee, Wisconsin, United States
Froedtert and the Medical College of Wisconsin
🇺🇸
Milwaukee, Wisconsin, United States
Aurora Sinai Medical Center
🇺🇸
Milwaukee, Wisconsin, United States
Southeast Cancer Center
🇺🇸
Cape Girardeau, Missouri, United States
Comprehensive Cancer Care and Research Institute of Colorado LLC
🇺🇸
Englewood, Colorado, United States
Mountain Blue Cancer Care Center
🇺🇸
Golden, Colorado, United States
Saint Anthony Hospital
🇺🇸
Lakewood, Colorado, United States
North Colorado Medical Center
🇺🇸
Greeley, Colorado, United States
McKee Medical Center
🇺🇸
Loveland, Colorado, United States
SCL Health Lutheran Medical Center
🇺🇸
Wheat Ridge, Colorado, United States
Cancer Center of Kansas - Newton
🇺🇸
Newton, Kansas, United States
Swedish Medical Center-Edmonds
🇺🇸
Edmonds, Washington, United States
Northwest Cancer Clinic
🇺🇸
Kennewick, Washington, United States
Saint Clare Hospital
🇺🇸
Lakewood, Washington, United States
Tacoma/Valley Radiation Oncology Centers-Puyallup
🇺🇸
Puyallup, Washington, United States
Jefferson Healthcare
🇺🇸
Port Townsend, Washington, United States
Virginia Mason Lynnwood Medical Center
🇺🇸
Lynnwood, Washington, United States
Providence Regional Cancer System-Shelton
🇺🇸
Shelton, Washington, United States
Rockwood Cancer Treatment Center-DHEC-Downtown
🇺🇸
Spokane, Washington, United States
Tacoma/Valley Radiation Oncology Centers-Jackson Hall
🇺🇸
Tacoma, Washington, United States
MultiCare Tacoma General Hospital
🇺🇸
Tacoma, Washington, United States
Tacoma/Valley Radiation Oncology Centers-Saint Joe's
🇺🇸
Tacoma, Washington, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn
🇺🇸
Auburn, California, United States
Kaiser Permanente Los Angeles Medical Center
🇺🇸
Los Angeles, California, United States
Mercy Medical Center-West Lakes
🇺🇸
West Des Moines, Iowa, United States
Siouxland Regional Cancer Center
🇺🇸
Sioux City, Iowa, United States
Illinois CancerCare-Kewanee Clinic
🇺🇸
Kewanee, Illinois, United States
Carle Physician Group-Mattoon/Charleston
🇺🇸
Mattoon, Illinois, United States
Crossroads Cancer Center
🇺🇸
Effingham, Illinois, United States
Illinois CancerCare-Eureka
🇺🇸
Eureka, Illinois, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
🇺🇸
Peoria, Illinois, United States
Illinois CancerCare-Princeton
🇺🇸
Princeton, Illinois, United States
Carle Cancer Center
🇺🇸
Urbana, Illinois, United States
Swedish Medical Center-First Hill
🇺🇸
Seattle, Washington, United States
OSF Saint Francis Medical Center
🇺🇸
Peoria, Illinois, United States
Methodist Medical Center of Illinois
🇺🇸
Peoria, Illinois, United States
Pacific Gynecology Specialists
🇺🇸
Seattle, Washington, United States
Rush-Copley Healthcare Center
🇺🇸
Yorkville, Illinois, United States
Good Samaritan Regional Health Center
🇺🇸
Mount Vernon, Illinois, United States
PeaceHealth Saint John Medical Center
🇺🇸
Longview, Washington, United States
Sutter Medical Center Sacramento
🇺🇸
Sacramento, California, United States
Kaiser Permanente-South Sacramento
🇺🇸
Sacramento, California, United States
Kaiser Permanente - Sacramento
🇺🇸
Sacramento, California, United States
The Medical Center of Aurora
🇺🇸
Aurora, Colorado, United States
University of Colorado Hospital
🇺🇸
Aurora, Colorado, United States
Walter Reed National Military Medical Center
🇺🇸
Bethesda, Maryland, United States
University of Michigan Comprehensive Cancer Center
🇺🇸
Ann Arbor, Michigan, United States
Wake Forest University Health Sciences
🇺🇸
Winston-Salem, North Carolina, United States
Northwest NCI Community Oncology Research Program
🇺🇸
Tacoma, Washington, United States
UPMC-Shadyside Hospital
🇺🇸
Pittsburgh, Pennsylvania, United States
Anchorage Radiation Therapy Center
🇺🇸
Anchorage, Alaska, United States
Alaska Breast Care and Surgery LLC
🇺🇸
Anchorage, Alaska, United States
Alaska Oncology and Hematology LLC
🇺🇸
Anchorage, Alaska, United States
Katmai Oncology Group
🇺🇸
Anchorage, Alaska, United States
Mills-Peninsula Medical Center
🇺🇸
Burlingame, California, United States
Loma Linda University Medical Center
🇺🇸
Loma Linda, California, United States
Memorial Medical Center
🇺🇸
Springfield, Illinois, United States
Palo Alto Medical Foundation Health Care
🇺🇸
Palo Alto, California, United States
Kaiser Permanente-Richmond
🇺🇸
Richmond, California, United States
Sutter Cancer Research Consortium
🇺🇸
Novato, California, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
🇺🇸
Roseville, California, United States
Kaiser Permanente-San Francisco
🇺🇸
San Francisco, California, United States
UCSF Medical Center-Mission Bay
🇺🇸
San Francisco, California, United States
Kaiser Permanente-Santa Rosa
🇺🇸
Santa Rosa, California, United States
Kaiser Permanente-San Rafael
🇺🇸
San Rafael, California, United States
Palo Alto Medical Foundation-Santa Cruz
🇺🇸
Santa Cruz, California, United States
Sutter Pacific Medical Foundation
🇺🇸
Santa Rosa, California, United States
Olive View-University of California Los Angeles Medical Center
🇺🇸
Sylmar, California, United States
Rocky Mountain Cancer Centers-Aurora
🇺🇸
Aurora, Colorado, United States
Rocky Mountain Cancer Centers-Boulder
🇺🇸
Boulder, Colorado, United States
Penrose-Saint Francis Healthcare
🇺🇸
Colorado Springs, Colorado, United States
Rocky Mountain Cancer Centers-Rose
🇺🇸
Denver, Colorado, United States
Swedish Medical Center
🇺🇸
Englewood, Colorado, United States
Rocky Mountain Cancer Centers-Sky Ridge
🇺🇸
Lone Tree, Colorado, United States
Littleton Adventist Hospital
🇺🇸
Littleton, Colorado, United States
Sky Ridge Medical Center
🇺🇸
Lone Tree, Colorado, United States
Longmont United Hospital
🇺🇸
Longmont, Colorado, United States
Rocky Mountain Cancer Centers-Longmont
🇺🇸
Longmont, Colorado, United States
Parker Adventist Hospital
🇺🇸
Parker, Colorado, United States
Rocky Mountain Cancer Centers-Parker
🇺🇸
Parker, Colorado, United States
Saint Mary Corwin Medical Center
🇺🇸
Pueblo, Colorado, United States
Hartford Hospital
🇺🇸
Hartford, Connecticut, United States
The Hospital of Central Connecticut
🇺🇸
New Britain, Connecticut, United States
Christiana Gynecologic Oncology LLC
🇺🇸
Newark, Delaware, United States
Medical Oncology Hematology Consultants PA
🇺🇸
Newark, Delaware, United States
Beebe Medical Center
🇺🇸
Lewes, Delaware, United States
Delaware Clinical and Laboratory Physicians PA
🇺🇸
Newark, Delaware, United States
Helen F Graham Cancer Center
🇺🇸
Newark, Delaware, United States
Beebe Health Campus
🇺🇸
Rehoboth Beach, Delaware, United States
Christiana Care Health System-Wilmington Hospital
🇺🇸
Wilmington, Delaware, United States
Northeast Georgia Medical Center-Gainesville
🇺🇸
Gainesville, Georgia, United States
Wilcox Memorial Hospital and Kauai Medical Clinic
🇺🇸
Lihue, Hawaii, United States
Memorial Hospital of Carbondale
🇺🇸
Carbondale, Illinois, United States
Illinois CancerCare-Canton
🇺🇸
Canton, Illinois, United States
Illinois CancerCare-Galesburg
🇺🇸
Galesburg, Illinois, United States
Western Illinois Cancer Treatment Center
🇺🇸
Galesburg, Illinois, United States
Carle Physician Group-Effingham
🇺🇸
Effingham, Illinois, United States
Illinois CancerCare-Peru
🇺🇸
Peru, Illinois, United States
Mary Greeley Medical Center
🇺🇸
Ames, Iowa, United States
Medical Oncology and Hematology Associates-West Des Moines
🇺🇸
Clive, Iowa, United States
McFarland Clinic PC-Jefferson
🇺🇸
Jefferson, Iowa, United States
University of Iowa/Holden Comprehensive Cancer Center
🇺🇸
Iowa City, Iowa, United States
Saint Luke's Regional Medical Center
🇺🇸
Sioux City, Iowa, United States
Cancer Center of Kansas - El Dorado
🇺🇸
El Dorado, Kansas, United States
Mercy Medical Center-Sioux City
🇺🇸
Sioux City, Iowa, United States
Cancer Center of Kansas-Independence
🇺🇸
Independence, Kansas, United States
Cancer Center of Kansas - Dodge City
🇺🇸
Dodge City, Kansas, United States
Cancer Center of Kansas - Fort Scott
🇺🇸
Fort Scott, Kansas, United States
Lawrence Memorial Hospital
🇺🇸
Lawrence, Kansas, United States
Kansas Institute of Medicine Cancer and Blood Center
🇺🇸
Lenexa, Kansas, United States
Menorah Medical Center
🇺🇸
Overland Park, Kansas, United States
Cancer Center of Kansas - Salina
🇺🇸
Salina, Kansas, United States
Saint Luke's South Hospital
🇺🇸
Overland Park, Kansas, United States
Kansas City NCI Community Oncology Research Program
🇺🇸
Prairie Village, Kansas, United States
Cancer Center of Kansas - Pratt
🇺🇸
Pratt, Kansas, United States
Associates In Womens Health
🇺🇸
Wichita, Kansas, United States
Cancer Center of Kansas - Wellington
🇺🇸
Wellington, Kansas, United States
Cancer Center of Kansas - Wichita
🇺🇸
Wichita, Kansas, United States
Via Christi Regional Medical Center
🇺🇸
Wichita, Kansas, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
🇺🇸
Wichita, Kansas, United States
Wichita NCI Community Oncology Research Program
🇺🇸
Wichita, Kansas, United States
Flaget Memorial Hospital
🇺🇸
Bardstown, Kentucky, United States
Oncology Hematology Care Inc-Crestview
🇺🇸
Crestview Hills, Kentucky, United States
Commonwealth Cancer Center-Corbin
🇺🇸
Corbin, Kentucky, United States
Cancer Center of Kansas - Winfield
🇺🇸
Winfield, Kansas, United States
Jewish Hospital Medical Center South
🇺🇸
Shepherdsville, Kentucky, United States
Woman's Hospital
🇺🇸
Baton Rouge, Louisiana, United States
Maine Medical Center- Scarborough Campus
🇺🇸
Scarborough, Maine, United States
Union Hospital of Cecil County
🇺🇸
Elkton, Maryland, United States
Brigham and Women's Hospital
🇺🇸
Boston, Massachusetts, United States
Baystate Medical Center
🇺🇸
Springfield, Massachusetts, United States
Dana-Farber Cancer Institute
🇺🇸
Boston, Massachusetts, United States
Bronson Methodist Hospital
🇺🇸
Kalamazoo, Michigan, United States
Weisberg Cancer Treatment Center
🇺🇸
Farmington Hills, Michigan, United States
Hickman Cancer Center
🇺🇸
Adrian, Michigan, United States
West Michigan Cancer Center
🇺🇸
Kalamazoo, Michigan, United States
Borgess Medical Center
🇺🇸
Kalamazoo, Michigan, United States
Mercy Memorial Hospital
🇺🇸
Monroe, Michigan, United States
Monroe Cancer Center
🇺🇸
Monroe, Michigan, United States
Toledo Clinic Cancer Centers-Monroe
🇺🇸
Monroe, Michigan, United States
Central Care Cancer Center - Bolivar
🇺🇸
Bolivar, Missouri, United States
Saint Dominic-Jackson Memorial Hospital
🇺🇸
Jackson, Mississippi, United States
University of Mississippi Medical Center
🇺🇸
Jackson, Mississippi, United States
Saint Francis Medical Center
🇺🇸
Cape Girardeau, Missouri, United States
Parkland Health Center-Bonne Terre
🇺🇸
Bonne Terre, Missouri, United States
Cox Cancer Center Branson
🇺🇸
Branson, Missouri, United States
Capital Region Southwest Campus
🇺🇸
Jefferson City, Missouri, United States
Centerpoint Medical Center LLC
🇺🇸
Independence, Missouri, United States
Freeman Health System
🇺🇸
Joplin, Missouri, United States
Saint Luke's East - Lee's Summit
🇺🇸
Lee's Summit, Missouri, United States
Liberty Radiation Oncology Center
🇺🇸
Liberty, Missouri, United States
Delbert Day Cancer Institute at PCRMC
🇺🇸
Rolla, Missouri, United States
Mercy Clinic-Rolla-Cancer and Hematology
🇺🇸
Rolla, Missouri, United States
Heartland Regional Medical Center
🇺🇸
Saint Joseph, Missouri, United States
Barnes-Jewish Hospital
🇺🇸
Saint Louis, Missouri, United States
Saint Louis Cancer and Breast Institute-South City
🇺🇸
Saint Louis, Missouri, United States
Missouri Baptist Medical Center
🇺🇸
Saint Louis, Missouri, United States
Sainte Genevieve County Memorial Hospital
🇺🇸
Sainte Genevieve, Missouri, United States
Cancer Research for the Ozarks NCORP
🇺🇸
Springfield, Missouri, United States
CoxHealth South Hospital
🇺🇸
Springfield, Missouri, United States
Mercy Hospital Springfield
🇺🇸
Springfield, Missouri, United States
Missouri Baptist Outpatient Center-Sunset Hills
🇺🇸
Sunset Hills, Missouri, United States
Missouri Baptist Sullivan Hospital
🇺🇸
Sullivan, Missouri, United States
Saint Vincent Healthcare
🇺🇸
Billings, Montana, United States
Billings Clinic Cancer Center
🇺🇸
Billings, Montana, United States
Bozeman Deaconess Hospital
🇺🇸
Bozeman, Montana, United States
Benefis Healthcare- Sletten Cancer Institute
🇺🇸
Great Falls, Montana, United States
Saint James Community Hospital and Cancer Treatment Center
🇺🇸
Butte, Montana, United States
Northern Montana Hospital
🇺🇸
Havre, Montana, United States
Kalispell Medical Oncology
🇺🇸
Kalispell, Montana, United States
Saint Peter's Community Hospital
🇺🇸
Helena, Montana, United States
Kalispell Regional Medical Center
🇺🇸
Kalispell, Montana, United States
Saint Patrick Hospital - Community Hospital
🇺🇸
Missoula, Montana, United States
Community Medical Hospital
🇺🇸
Missoula, Montana, United States
CHI Health Good Samaritan
🇺🇸
Kearney, Nebraska, United States
Heartland Hematology and Oncology
🇺🇸
Kearney, Nebraska, United States
Midlands Community Hospital
🇺🇸
Papillion, Nebraska, United States
Cooper Hospital University Medical Center
🇺🇸
Camden, New Jersey, United States
Renown Regional Medical Center
🇺🇸
Reno, Nevada, United States
Memorial Sloan Kettering Basking Ridge
🇺🇸
Basking Ridge, New Jersey, United States
Dartmouth Hitchcock Medical Center
🇺🇸
Lebanon, New Hampshire, United States
Center of Hope at Renown Medical Center
🇺🇸
Reno, Nevada, United States
MD Anderson Cancer Center at Cooper-Voorhees
🇺🇸
Voorhees, New Jersey, United States
Southwest Gynecologic Oncology Associates Inc
🇺🇸
Albuquerque, New Mexico, United States
Women's Cancer Care Associates LLC
🇺🇸
Albany, New York, United States
Memorial Sloan Kettering Commack
🇺🇸
Commack, New York, United States
Memorial Sloan Kettering Westchester
🇺🇸
Harrison, New York, United States
Memorial Sloan Kettering Cancer Center
🇺🇸
New York, New York, United States
University of Rochester
🇺🇸
Rochester, New York, United States
Memorial Sloan Kettering Rockville Centre
🇺🇸
Rockville Centre, New York, United States
State University of New York Upstate Medical University
🇺🇸
Syracuse, New York, United States
AdventHealth Infusion Center Asheville
🇺🇸
Asheville, North Carolina, United States
Memorial Sloan Kettering Sleepy Hollow
🇺🇸
Sleepy Hollow, New York, United States
Stony Brook University Medical Center
🇺🇸
Stony Brook, New York, United States
Carolinas Medical Center/Levine Cancer Institute
🇺🇸
Charlotte, North Carolina, United States
Cone Health Cancer Center at Alamance Regional
🇺🇸
Burlington, North Carolina, United States
Novant Health Presbyterian Medical Center
🇺🇸
Charlotte, North Carolina, United States
Southern Oncology Specialists-Charlotte
🇺🇸
Charlotte, North Carolina, United States
Cone Health Cancer Center
🇺🇸
Greensboro, North Carolina, United States
Lake Norman Hematology Oncology Specialists-Mooresville
🇺🇸
Mooresville, North Carolina, United States
Cone Heath Cancer Center at Mebane
🇺🇸
Mebane, North Carolina, United States
Annie Penn Memorial Hospital
🇺🇸
Reidsville, North Carolina, United States
Sanford Bismarck Medical Center
🇺🇸
Bismarck, North Dakota, United States
Summa Akron City Hospital/Cooper Cancer Center
🇺🇸
Akron, Ohio, United States
Saint Alexius Medical Center
🇺🇸
Bismarck, North Dakota, United States
Toledo Clinic Cancer Centers-Bowling Green
🇺🇸
Bowling Green, Ohio, United States
Oncology Hematology Care Inc-Mercy West
🇺🇸
Cincinnati, Ohio, United States
Miami Valley Hospital South
🇺🇸
Centerville, Ohio, United States
Aultman Health Foundation
🇺🇸
Canton, Ohio, United States
Oncology Hematology Care Inc - Anderson
🇺🇸
Cincinnati, Ohio, United States
Columbus Oncology and Hematology Associates Inc
🇺🇸
Columbus, Ohio, United States
Ohio State University Comprehensive Cancer Center
🇺🇸
Columbus, Ohio, United States
Riverside Methodist Hospital
🇺🇸
Columbus, Ohio, United States
Columbus NCI Community Oncology Research Program
🇺🇸
Columbus, Ohio, United States
Doctors Hospital
🇺🇸
Columbus, Ohio, United States
Miami Valley Hospital North
🇺🇸
Dayton, Ohio, United States
Dayton Physician LLC-Miami Valley Hospital North
🇺🇸
Dayton, Ohio, United States
Delaware Health Center-Grady Cancer Center
🇺🇸
Delaware, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital
🇺🇸
Franklin, Ohio, United States
Grady Memorial Hospital
🇺🇸
Delaware, Ohio, United States
Greater Dayton Cancer Center
🇺🇸
Kettering, Ohio, United States
Dayton Physicians LLC-Atrium
🇺🇸
Franklin, Ohio, United States
Newark Radiation Oncology
🇺🇸
Newark, Ohio, United States
Dayton Physicians LLC-Signal Point
🇺🇸
Middletown, Ohio, United States
UH Seidman Cancer Center at Landerbrook Health Center
🇺🇸
Mayfield Heights, Ohio, United States
Saint Charles Hospital
🇺🇸
Oregon, Ohio, United States
Licking Memorial Hospital
🇺🇸
Newark, Ohio, United States
Toledo Clinic Cancer Centers-Oregon
🇺🇸
Oregon, Ohio, United States
The Toledo Hospital/Toledo Children's Hospital
🇺🇸
Toledo, Ohio, United States
Saint Vincent Mercy Medical Center
🇺🇸
Toledo, Ohio, United States
ProMedica Flower Hospital
🇺🇸
Sylvania, Ohio, United States
Mercy Saint Anne Hospital
🇺🇸
Toledo, Ohio, United States
Toledo Community Hospital Oncology Program CCOP
🇺🇸
Toledo, Ohio, United States
Oklahoma Cancer Specialists and Research Institute-Tulsa
🇺🇸
Tulsa, Oklahoma, United States
Genesis Healthcare System Cancer Care Center
🇺🇸
Zanesville, Ohio, United States
Abington Memorial Hospital
🇺🇸
Abington, Pennsylvania, United States
Providence Willamette Falls Medical Center
🇺🇸
Oregon City, Oregon, United States
Bay Area Hospital
🇺🇸
Coos Bay, Oregon, United States
Cherry Tree Cancer Center
🇺🇸
Hanover, Pennsylvania, United States
Saint Luke's University Hospital-Bethlehem Campus
🇺🇸
Bethlehem, Pennsylvania, United States
Legacy Meridian Park Hospital
🇺🇸
Tualatin, Oregon, United States
Ephrata Cancer Center
🇺🇸
Ephrata, Pennsylvania, United States
UPMC-Heritage Valley Health System Beaver
🇺🇸
Beaver, Pennsylvania, United States
Geisinger Medical Center
🇺🇸
Danville, Pennsylvania, United States
Geisinger Medical Center-Cancer Center Hazleton
🇺🇸
Hazleton, Pennsylvania, United States
Adams Cancer Center
🇺🇸
Gettysburg, Pennsylvania, United States
UPMC Cancer Center at UPMC McKeesport
🇺🇸
McKeesport, Pennsylvania, United States
Armstrong Center for Medicine and Health
🇺🇸
Kittanning, Pennsylvania, United States
UPMC-Johnstown/John P. Murtha Regional Cancer Center
🇺🇸
Johnstown, Pennsylvania, United States
UPMC-Coraopolis/Heritage Valley Radiation Oncology
🇺🇸
Moon, Pennsylvania, United States
UPMC Washington Hospital Radiation Oncology
🇺🇸
Washington, Pennsylvania, United States
UPMC Cancer Center at UPMC Northwest
🇺🇸
Seneca, Pennsylvania, United States
Reading Hospital
🇺🇸
West Reading, Pennsylvania, United States
Greenville Health System Cancer Institute-Eastside
🇺🇸
Greenville, South Carolina, United States
Greenville Health System Cancer Institute-Andrews
🇺🇸
Greenville, South Carolina, United States
University of Tennessee - Knoxville
🇺🇸
Knoxville, Tennessee, United States
MultiCare Auburn Medical Center
🇺🇸
Auburn, Washington, United States
Providence Regional Cancer System-Aberdeen
🇺🇸
Aberdeen, Washington, United States
PeaceHealth Saint Joseph Medical Center
🇺🇸
Bellingham, Washington, United States
Virginia Mason Federal Way Medical Center
🇺🇸
Federal Way, Washington, United States
Providence Regional Cancer Partnership
🇺🇸
Everett, Washington, United States
Harrison Medical Center
🇺🇸
Bremerton, Washington, United States
Tacoma/Valley Radiation Oncology Centers-Gig Harbor
🇺🇸
Gig Harbor, Washington, United States
Rockwood Clinic Cancer Treatment Center-Valley
🇺🇸
Spokane Valley, Washington, United States
Providence Saint Mary Regional Cancer Center
🇺🇸
Walla Walla, Washington, United States
Monongalia Hospital
🇺🇸
Morgantown, West Virginia, United States
Aurora Health Center-Fond du Lac
🇺🇸
Fond Du Lac, Wisconsin, United States
Aurora Cancer Care-Grafton
🇺🇸
Grafton, Wisconsin, United States
Aurora BayCare Medical Center
🇺🇸
Green Bay, Wisconsin, United States
Gundersen Lutheran Medical Center
🇺🇸
La Crosse, Wisconsin, United States
UW Cancer Center Johnson Creek
🇺🇸
Johnson Creek, Wisconsin, United States
Aurora Bay Area Medical Group-Marinette
🇺🇸
Marinette, Wisconsin, United States
Aurora Medical Center in Summit
🇺🇸
Summit, Wisconsin, United States
Vince Lombardi Cancer Clinic-Sheboygan
🇺🇸
Sheboygan, Wisconsin, United States
Vince Lombardi Cancer Clinic-Two Rivers
🇺🇸
Two Rivers, Wisconsin, United States
Aurora West Allis Medical Center
🇺🇸
West Allis, Wisconsin, United States
Centre Leon Berard
🇫🇷
Lyon, France
Centre Catherine de Sienne
🇫🇷
Nantes, France
University of Oslo
🇳🇴
Oslo, Norway
Beatson Oncology Center
🇬🇧
Glasgow, Scotland, United Kingdom
University Medical Center Groningen
🇳🇱
Groningen, Netherlands
Providence Alaska Medical Center
🇺🇸
Anchorage, Alaska, United States
Rocky Mountain Cancer Centers-Penrose
🇺🇸
Colorado Springs, Colorado, United States
Ochsner Medical Center Jefferson
🇺🇸
New Orleans, Louisiana, United States
Montana Cancer Consortium NCORP
🇺🇸
Billings, Montana, United States
Saint Vincent Frontier Cancer Center
🇺🇸
Billings, Montana, United States
Glacier Oncology PLLC
🇺🇸
Kalispell, Montana, United States
Christie Hospital
🇬🇧
Manchester, England, United Kingdom
Hospital Universitario
🇻🇪
Caracas, Venezuela
Florida Urology Associates-Orlando
🇺🇸
Orlando, Florida, United States
Florida Hospital East Orlando
🇺🇸
Orlando, Florida, United States
Florida Hospital Orlando
🇺🇸
Orlando, Florida, United States
Saints Mary and Elizabeth Hospital
🇺🇸
Louisville, Kentucky, United States
Jewish Hospital
🇺🇸
Louisville, Kentucky, United States
Jewish Hospital Medical Center Northeast
🇺🇸
Louisville, Kentucky, United States
Saint Luke's Hospital of Kansas City
🇺🇸
Kansas City, Missouri, United States
Research Medical Center
🇺🇸
Kansas City, Missouri, United States
Heartland Hematology and Oncology Associates Incorporated
🇺🇸
Kansas City, Missouri, United States
Medical University of South Carolina
🇺🇸
Charleston, South Carolina, United States
Hawaii Oncology Inc-POB I
🇺🇸
Honolulu, Hawaii, United States
Hawaii Cancer Care Inc-POB II
🇺🇸
Honolulu, Hawaii, United States
Island Urology
🇺🇸
Honolulu, Hawaii, United States
Queen's Medical Center
🇺🇸
Honolulu, Hawaii, United States
Straub Clinic and Hospital
🇺🇸
Honolulu, Hawaii, United States
Hawaii Cancer Care Inc-Liliha
🇺🇸
Honolulu, Hawaii, United States
Hawaii Oncology Inc-Kuakini
🇺🇸
Honolulu, Hawaii, United States
Kuakini Medical Center
🇺🇸
Honolulu, Hawaii, United States
The Cancer Center of Hawaii-Liliha
🇺🇸
Honolulu, Hawaii, United States
University of Hawaii Cancer Center
🇺🇸
Honolulu, Hawaii, United States
Kaiser Permanente Moanalua Medical Center
🇺🇸
Honolulu, Hawaii, United States
Kapiolani Medical Center for Women and Children
🇺🇸
Honolulu, Hawaii, United States
Tripler Army Medical Center
🇺🇸
Honolulu, Hawaii, United States
Iowa Methodist Medical Center
🇺🇸
Des Moines, Iowa, United States
Iowa-Wide Oncology Research Coalition NCORP
🇺🇸
Des Moines, Iowa, United States
Medical Oncology and Hematology Associates-Des Moines
🇺🇸
Des Moines, Iowa, United States
Medical Oncology and Hematology Associates-Laurel
🇺🇸
Des Moines, Iowa, United States
Mercy Medical Center - Des Moines
🇺🇸
Des Moines, Iowa, United States
Iowa Lutheran Hospital
🇺🇸
Des Moines, Iowa, United States
Saint Joseph Radiation Oncology Resource Center
🇺🇸
Lexington, Kentucky, United States
Saint Joseph Hospital East
🇺🇸
Lexington, Kentucky, United States
University of Wisconsin Hospital and Clinics
🇺🇸
Madison, Wisconsin, United States
Wesley Medical Center
🇺🇸
Wichita, Kansas, United States
UC San Diego Moores Cancer Center
🇺🇸
La Jolla, California, United States
Methodist West Hospital
🇺🇸
West Des Moines, Iowa, United States
Carilion Clinic Gynecological Oncology
🇺🇸
Roanoke, Virginia, United States
Armes Family Cancer Center
🇺🇸
Findlay, Ohio, United States
Inova Fairfax Hospital
🇺🇸
Falls Church, Virginia, United States
Sutter Davis Hospital
🇺🇸
Davis, California, United States
Southern Ohio Medical Center
🇺🇸
Portsmouth, Ohio, United States
Southern Oncology Specialists-Huntersville
🇺🇸
Huntersville, North Carolina, United States
UTMB Cancer Center at Victory Lakes
🇺🇸
League City, Texas, United States

Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or Observation in Treating Patients With High-Risk Uterine Leiomyosarcoma Previously Removed by Surgery

Recruitment & Eligibility

Study & Design

Trial Locations

Instant Trial Alerts

Instant Trial Alerts