A Study on the Metabolic Pathway of Tryptophan and Executive Dysfunction in Children With Attention Deficit Hyperactivity Disorder
试验速览
- 阶段
- 不适用
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Serum level of Indolepropionic acid [IPA]
研究概览
简要总结
The present project is to identify the relationship between ADHD and the metabolites of tryptophan.
详细描述
Because attention deficit hyperactivity disorder (ADHD) is an early onset and long-term impairing disorder with tremendous impact on individuals, families, and societies, detection and diagnosis are very important for ADHD. According to investigators previous work, participants with ADHD have executive dysfunction. Previous studies show that tryptophan is associated with cognitive problems in participants. Analyzing differences in tryptophan metabolites (Indolepropionic acid [IPA], indoleacetic acid [IAA], and kynurenic acid [KYNA]) between participants with ADHD and healthy controls could provide insight into underlying disease pathology of cognitive deficits. In this one-year project, investigators will perform an analysis of tryptophan metabolites in serum to identify potential biomarkers for the executive dysfunction of ADHD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 7 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Serum level of Indolepropionic acid [IPA]
时间窗: 1 year
tryptophan metabolite
Serum level of indoleacetic acid [IAA]
时间窗: 1 year
tryptophan metabolite
Serum level of kynurenic acid [KYNA]
时间窗: 1 year
tryptophan metabolite
次要结局
- Swanson, Nolan, and Pelham IV scale(1 year)
- Continuous Performance Test(1 year)
- Social Adjustment Inventory for Children and Adolescents(1 year)
- Cambridge Neuropsychological Test Automated Batteries(1 year)
- Clinical Global Impressions-ADHD-Severity(1 year)
- ADHD Rating Scale-IV(1 year)
- Achenbach Child Behavior Checklist(1 year)
- Chinese version of the Family Adaptation, Partnership, Growth, Affection, and Resolve(1 year)