Development of Clinical Assessment Technique Using Multi-radiotracer PET/MR in Prostate Cancer
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- accuracy of PET/MR predicting localization and staging of prostate cancer
Study Overview
Brief Summary
To development of clinical assessment technique using multi-radiotracer positron emission tomography/magnetic resonance (PET/MR) in prostate cancer
- to establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer
- to establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer and early detection of recurrent prostate cancer
Detailed Description
To establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer
- Recruiting 30 patients with prostate cancer ahead to radical prostatectomy
- PET/MR using 18F-choline with dedicated prostate MRI in all patients
- PET/MR using 18fluoride(F)-fluorodeoxyglucose(FDG)in all patients after 2-7 days
- PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR
- outcome assessment: comparison of scan time, image quality, tumor detection rate, standardized uptake values of lesions
- establishing optimal imaging technique for prostate PET/MR
To establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer
- comparison of findings on PET/MR, MRI and PET/CT with pathological mapping after radical prostatectomy
- outcome assessment: accuracy of PET/MR for localization and staging of prostate cancer compared with MRI only and PET/CT only
To establish the imaging biomarker using PET/MR for early detection of recurrent prostate cancer
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patient with prostate cancer before treatment
- •patient with prostate cancer treated
- •patient with prostate cancer recurrent
Exclusion Criteria
- •patient with contraindication for MRI
- •Patient with severe renal impairment
Arms & Interventions
PET/MR
Multi-radiotracer PET/MR will be performed to compare the accuracy of tumor detection in patient with primary prostate cancer
Intervention: PET/MR (Device)
Outcomes
Primary Outcomes
accuracy of PET/MR predicting localization and staging of prostate cancer
Time Frame: 1 week after radical prostatectomy
analysis of accuracy of PET/MR predicting localization and staging of prostate cancer by comparison of PET/MR findings with pathological mapping images after radical prostatectomy
Secondary Outcomes
- accuracy of early detection and localization of recurrent prostate cancer(1 week after PET/MR imaging)