Optimizing Mothers' Milk for Preterm Infants (OptiMoM) Program of Research: Study 1-Impact of Donor Milk at Kindergarten
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infant, Very Low Birth Weight
- Sponsor
- The Hospital for Sick Children
- Enrollment
- 158
- Locations
- 1
- Primary Endpoint
- Full-Scale IQ on the Wechsler Preschool and Primary Scale of Intelligence-IV (WPPSI-IV)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
In Canada, the leading cause of long-term disability in children is being born at very low birth weight (VLBW). To help improve outcomes, nutrition is a modifiable aspect of infant care. Mother's milk is the optimal way to feed VLBW infants; however, many need a supplement of donor milk or preterm formula as not enough mother's milk is available. As the ideal supplement for prolonged feeding and its long-term effects is currently unknown, this study is a prospective follow up of VLBW infants who in hospital were fed: donor milk or preterm formula and/or mother's milk. Areas of development to be assessed include: cognition, language, motor skills, brain structure/function, and body composition. A DNA biorepository will also be created.
Investigators
Deborah O'Connor
Senior Associate Scientist, Research Institute
The Hospital for Sick Children
Eligibility Criteria
Inclusion Criteria
- •Children who were enrolled in the DoMINO (Donor Milk for Improved Neurodevelopmental Outcomes) trial (ISRCTN35317141).
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Full-Scale IQ on the Wechsler Preschool and Primary Scale of Intelligence-IV (WPPSI-IV)
Time Frame: 5.5 years of age
Secondary Outcomes
- General Language Composite on the WPPSI-IV(5.5 years of age)
- Verbal IQ on the WPPSI-IV(5.5 years of age)
- Performance IQ on the WPPSI-IV(5.5 years of age)
- Processing Speed Quotient on the WPPSI-IV(5.5 years of age)
- Growth(5.5 years of age)
- Body Composition(5.5 years of age)