A double blind randomized controlled study to evaluate the efficacy of different doses of oral Channa striatus extract versus Glucosamine Sulphate among knee osteoarthritis patients

niversiti Sains Malaysia0 个研究点目标入组 156 人开始时间: 2015年8月27日最近更新: 2020年1月13日

适应症

试验速览

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•1-All patients with unilateral or bilateral knee osteoarthritis according to clinical and radiological criteria of the American College of Rheumatology (ACR) (Altman et al. 1986)
•Knee pain and radiographic osteophytes plus at least one of three symptoms/signs listed below:
•-age more than 40 years OR
•-stiffness less than 30 minutes OR
•-crepitus.
•This criteria is widely accepted as the standard diagnosis criteria for knee OA with 91% sensitivity and 86% specificity.
•2-Have a radiological grade between I and III, as measured with the Kellgren-Lawrence method of Classification.
•3-Patients have symptoms for at least three months.

•1-Patient with secondary knee osteoarthritis, such as post traumatic OA, inflammatory arthritis, specifically rheumatoid arthritis, active gout
•2-Disabling co-morbid condition such as renal disease, liver disease, neoplasm, and other rheumatic diseases.
•3-Pregnancy or nursing.
•4-Patient with severe knee pain and willing for surgical intervention.
•5-Those who had joint lavage, arthroscopy, or treatment with hyaluronic acid during the previous 6 months.
•6-Patient who had been treated with intra-articular corticosteroids during the past 3 months.
•7-Patient who have allergic to oral C.striatus or Glucosamine

发起方

niversiti Sains Malaysia