Effect of intra-articular Triamcinolone and combined Ketorolac-Triamcinolone injection in treatment of patient with primary osteoarthritis; A Randomized controlled trial

Phase 3

• Conditions: Primary osteoarthritis; Ketorolac tromethamine; Triamcinolone acetonide

• Registration Number: TCTR20210728004
• Lead Sponsor: Faculty of medicine, prince of songkla university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-28
• Study Completion: 2022-05-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1 Age older than 45 years old
2 Patient who was diagnosed as primary osteoarthritis by ACR criteria with knee pain more than 3 months
3 Patient who were radiologically classified in Kellgren and Lawrence classification 2 or 3
4 VAS more than 4

Exclusion Criteria

1 History of knee replacement or open knee surgery
2 Previous arthroscopic knee procedure within 6 months prior
3 Previous intraarticular injection within 3 months prior
4 Allergy of NSAIDs Corticosteroid and Lidocaine
5 Currently usage of anticoagulants corticosteroid and indomethacin
6 Patient with severely impaired cognitive function which is unable to evaluate outcomes and follow research protocol
7 Patient with severely illness such as poor controlled diabetes mellitus HbA1C more than 7.5%
8 Significant chronic kidney disease; GFR < 60 mL/minute within past 1 month
9 Patient who is currently or recently participating in any clinical trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain score at 1 and 3 month Visual analog scale

Secondary Outcome Measures

Name	Time	Method
Functional score at 1, 3 and 6 months KOOS score ,Pain score at 6 months Visual analog scale,Adverse effect at 1,3 and 6 months Questionnaire