INSPIRE Trial for Skin and Soft Tissue Infections
- Conditions
- Skin and Soft Tissue (SST) Infection
- Registration Number
- NCT05423756
- Lead Sponsor
- Harvard Pilgrim Health Care
- Brief Summary
The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with skin and soft tissue infection is infected with a resistant pathogen.
Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 102
- HCA Healthcare hospitals admitting adults for skin and soft tissue infection
- Facility use of MEDITECH as their electronic health record system
Facility
Note: unit of randomization is the hospital, however the computerized physician order entry (CPOE) alert intervention will calculate risk estimates for adults age >=18 admitted to non-intensive care unit wards and who are ordered to receive extended-spectrum antibiotics for skin and soft tissue infection.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Empiric Extended-Spectrum Antibacterial Days of Therapy (Empiric ES-DOT) 12 month intervention The number of different extended-spectrum antibacterials on each of the first 3 days of hospitalization.
- Secondary Outcome Measures
Name Time Method Antipseudomonal Antibiotic Days of Therapy per Empiric Day 12 months The number of different antipseudomonal antibiotics, per empiric day, summed across the first 3 days of hospitalization.
Trial Locations
- Locations (102)
Riverside Community hospital
🇺🇸Riverside, California, United States
Regional Medical Center of San Jose
🇺🇸San Jose, California, United States
Good Samaritan Hospital
🇺🇸San Jose, California, United States
Los Robles Hospital & Medical Center
🇺🇸Thousand Oaks, California, United States
West Hills Hospital & Medical Center
🇺🇸West Hills, California, United States
The Medical Center of Aurora
🇺🇸Aurora, Colorado, United States
Swedish Medical Center
🇺🇸Englewood, Colorado, United States
Sky Ridge Medical Center
🇺🇸Lone Tree, Colorado, United States
North Suburban Medical Center
🇺🇸Thornton, Colorado, United States
Blake Medical Center
🇺🇸Bradenton, Florida, United States
Scroll for more (92 remaining)Riverside Community hospital🇺🇸Riverside, California, United States