VExUS-guided Fluid Management in Patients With Acute Kidney Injury in the Intensive Care Unit
试验速览
- 阶段
- 不适用
- 入组人数
- 55
- 试验地点
- 2
- 主要终点
- Renal replacement therapy
研究概览
简要总结
A quasi experimental study that aims to verify whether the incorporation of VExUS in patients with AKI in the Intensive Care Unit (ICU) may prompt tailored interventions to increases the number of days free from Renal Replacement Therapy (RRT) during the first 28 days.
详细描述
Fluid overload is associated with organ dysfunction, such as Acute Kidney Injury (AKI), and increased mortality. It remains unclear if fluid overload is merely an epiphenomenon in critically ill patients or if organ congestion is a mediator of complications. Considering AKI related to fluid overload, diuretic therapy would reduce venous congestion and improve renal blood flow. The Venous Excess Ultrasound score (VExUS) identifies clinically significant venous congestion and indicates a high risk of post-operative AKI. This quasi-experimental study aims to verify whether the incorporation of VExUS in patients with AKI in the Intensive Care Unit (ICU) may prompt tailored interventions to increases the number of days free from Renal Replacement Therapy (RRT) during the first 28 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-elective ICU admission
- •Severe acute kidney injury (AKI) defined either: A ≥ 2-fold increase in serum creatinine from a known pre-morbid baseline or during the current hospitalization OR Urine output < 6.0 mL/kg over the preceding 12 hours
排除标准
- •Life-threatening indication of RRT (defined as intractable hyperkalaemia, acidosis, uraemic symptoms) at Day 0
- •RRT before recruitment
- •Use of Extracorporeal membrane oxygenation (ECMO)
- •Hepatic cirrhosis or other condition with portal hypertension
- •Lack of commitment to provide RRT as part of limitation of ongoing life support
- •Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate < 30 mL/min/1.73 m2 or chronic RRT
- •Refusal to sign the informed consent form
结局指标
主要结局
Renal replacement therapy
时间窗: Day 28
Number of days free from renal replacement therapy during the first 28 days
次要结局
- Mortality(Day 28)
- KDIGO category for AKI(48 hours)