Pancreatic exocrine insufficiency in children with acute pancreatitis
Not Applicable
Completed
- Conditions
- Health Condition 1: K00-K95- Diseases of the digestive system
- Registration Number
- CTRI/2021/07/035280
- Lead Sponsor
- ot funded
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Children with acute pancreatitis admitted in hospital. Control subjects are age and sex matched normal children
Exclusion Criteria
Children with chronic pancreatitis, liver disorders, Cholestasis, short bowel syndrome, Small bowel mucosal diseases, Celiac disease, Inflammatory bowel disease, Surgical intervention on the gastrointestinal tract, Zollinger-Ellison syndrome will be excluded. Children who are on nutritional supplementation, who have had any major illness over the last 3 months, Recent diarrhoea within a month, Febrile illness or NSAID usage a month prior to illness will also be excluded.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To determine whether children (aged 8-15y) with acute pancreatitis have reduced fat digestibility in comparison to control childrenTimepoint: 13C mixed chain triglyceride meal will be administered in both cases and controls and breath samples will be collected and analyzed over a period of 6 hours. <br/ ><br>Follow up study will be done after 1 month of illness in cases. <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1)To characterize the metabolic profile of children with Acute Pancreatitis (AP) through plasma lipidomics, in comparison with normal children <br/ ><br>2) To measure serum nutritional biomarkers & micronutrient levels in children with Acute Pancreatitis compared to normal children <br/ ><br>Timepoint: Baseline