A study to assess Biological imaging before, during, and after Simultaneous Modulated Accelerated Radiation Therapy in head and neck squamous cell carcinoma .
Not Applicable
- Conditions
- Health Condition 1: null- Head Neck Squamous Cell Carcinoma
- Registration Number
- CTRI/2013/09/003988
- Lead Sponsor
- Tata Memorial Centre Tata Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1.Patients >18 yrs and <=65 yrs
2.Biopsy proven squamous carcinoma of the oropharynx, larynx or hypopharynx
3.T stage â?? T1 to T3
4.N stage â?? N1 to N2c
5.Planned for definitive non- surgical treatment (radiotherapy with or without systemic chemotherapy)
6.ECOG PS 0 to1
Exclusion Criteria
1.Metastatic disease
2.Prior history of malignancy
3.Prior treatment interventions for the index malignancy (lymph node biopsies allowed)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To standardise the image acquisition with F-MISO PET.Timepoint: pre RT
- Secondary Outcome Measures
Name Time Method To assess changes in tumour characteristics using serial functional imaging with PET-CT (FDG & F-MISO) and MRI (DWI & DSC) in patients with HNSCC over a course of fractionated (chemo) radiotherapy.Timepoint: 9-12 months