Pk/Pd aspects of linezolid in critically ill patients with late onset Ventilator-Associated Pneumonia. Intermittent versus Continuous Infusion Introduction - ND

POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI0 个研究点开始时间: 2010年12月24日最近更新: 2012年4月3日

试验速览

暂无简介。

•all critically ill adult patients who are mechanically ventilated in Intensive Care Unit (ICU) for more than 96 hours developing VAP (CPIS value=6 or new and persistent infiltrate on chest radiography without another obvious cause associated with any two of the following conditions: purulent tracheal secretions, temperature of 38.?C or higher, leukocyte count higher than 11000/µL or lower than 3500/µL, increasing oxygen requirements, recent finding of pathogenic bacteria from respiratory secretions). Anuric patients can be enrolled if they are yet receiving CVVHDF.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•are < 18 years
•are pregnant
•are allergic to linezolid
•have creatinine clereance ClCR <40 ml/min (calculated according to Cocrockft-Gault formula), with the exception of anuric ones undergoing CVVHDF
•present thrombocytopenia (platelets count<80000/mmc)
•have severe hepatic failure (Child-Pugh C)
•have little chance of survival as defined by Symplified Acute Physiology Score (SAPS II)
•are treated with other drugs that can potentially interfere with linezolid (i.e. erythromycin, serotonin modulators).
•Absence of infromed consent

发起方

POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI